Level of human lactoferrin in whole saliva, research for risk factors for periodontal disease

全唾液中人乳铁蛋白的水平及牙周病危险因素的研究

• 批准号: 16592084
• 负责人: KANEHIRA Takashi
• 金额: $ 1.73万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2004
• 资助国家: 日本
• 起止时间: 2004 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16592084/
• 关键词: Whole Saliva; Lactoferrin; Periodontal Disease; 個人差

The purpose of this study was to measure the levels of human lactoferrin in whole saliva among various age groups and examine the relationship between levels of lactoferrin and periodontal status. Whole saliva sample from donors (n=351) were collected by gum stimulation in ten minutes. The levels of lactoferrin were determined by the enzyme-linked immunosorbent assay (ELISA) using a monoclonal antibody. The results were as follows:1)The levels of lactoferrin in 60's and 70's year old group increased significantly than those under 30's year old groups. 2) Relationships between the levels of lactoferrin and periodontal status were unclear.

本研究的目的是测量不同年龄组的全唾液中人乳铁蛋白的水平，并研究乳铁蛋白水平与牙周状况之间的关系。在10分钟内通过牙龈刺激收集来自供体（n=351）的全唾液样品。使用单克隆抗体通过酶联免疫吸附测定（ELISA）测定乳铁蛋白的水平。结果表明：1）60岁和70岁组乳铁蛋白水平显著高于30岁以下组; 2)乳铁蛋白水平和牙周状况之间的关系尚不清楚。

项目成果

ラクトフェリン研究の新たな展望と応用のメッセージ2006

2006年乳铁蛋白研究新前景及应用信息

• 发表时间: 2007
• 作者: 夫馬大介;稲垣幸司;石原祐一他;兼平 孝ほか共著
• 通讯作者: 兼平 孝ほか共著