Study for sentinel lymph node detection by nuclear medical method in oral cancer

核医学方法检测口腔癌前哨淋巴结的研究

基本信息

  • 批准号:
    14370657
  • 负责人:
  • 金额:
    $ 5.89万
  • 依托单位:
  • 依托单位国家:
    日本
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
  • 财政年份:
    2002
  • 资助国家:
    日本
  • 起止时间:
    2002 至 2004
  • 项目状态:
    已结题

项目摘要

Background and Aims : Sentinel lymph node navigation is expected to reduce the need for lymph node dissection in cancer surgery. We studied whether the sentinel lymph node concept is applicable to oral cancer.Patients and methods : Subjects were 7 patients with oral squamous cell carcinoma undergoing primary resection and neck dissection between April 2002 and July 2003. They were injected with 99mTc labeled phytate surrounding primary lesion for tracers preoperatively. Preoperative lymphoscintigraphy and intraoperative identification by gamma probe were done to detect sentinel lymph nodes. Dissected lymph nodes were examined histopathologically and nuclear-radiologically.Results : Sentinel lymph nodes were recognized at the submandibular region in all patients, and additional nodes at the cervical region in 3 cases. Metastatases were identified in 3 cases, one of whom had multiple metastases downstream from the sentinel lymph node. Another had further metastasis outside the dissection area.Conclusion : Sentinel lymph nodes are detected as described above and the sentinel lymph node concept is reasonable for oral cancer application.
背景和目的:前哨淋巴结导航有望减少癌症手术中淋巴结清扫的需求。我们研究了前哨淋巴结的概念是否适用于口腔cancer.Patients和方法:受试者是7例口腔鳞状细胞癌进行原发性切除和颈淋巴结清扫术之间2002年4月和2003年7月。术前在原发灶周围注射99mTc标记的植酸盐作为示踪剂。术前行淋巴结造影,术中用伽玛刀定位前哨淋巴结。结果:所有病例均在颌下区发现前哨淋巴结,3例在颈部发现前哨淋巴结。在3例病例中发现转移,其中1例在前哨淋巴结下游发现多处转移。结论:前哨淋巴结检测如上所述,前哨淋巴结的概念是合理的口腔癌的应用。

项目成果

期刊论文数量(43)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Uzawa, N., Negishi, A., et al.: "Loss of heterozygosity on the short arm of chromosome 3 in orel squamous cell carcinomas -Relationship between loss of heterozygosity on 3p25-ter region and clinical and histological features-"Dentistry in Japan. 38. 63-66
Uzawa, N., Negishi, A., et al.:“orel 鳞状细胞癌中 3 号染色体短臂杂合性丢失 - 3p25-ter 区域杂合性丢失与临床和组织学特征之间的关系 -”牙科
  • DOI:
  • 发表时间:
  • 期刊:
  • 影响因子:
    0
  • 作者:
  • 通讯作者:
口腔領域におけるセンチネルリンパ節理論の検証
口腔前哨淋巴结理论的验证
  • DOI:
  • 发表时间:
    2005
  • 期刊:
  • 影响因子:
    0
  • 作者:
    根岸明秀;中曽根良樹;他
  • 通讯作者:
Sagittal splitting ramous osteotomy for orthognathic surgery
正颌手术矢状劈裂截骨术
Gilles de la Tourette' syndoromeによる舌咬傷に対しスプリント療法が有効であった1例
夹板治疗抽动秽语综合征咬舌有效一例
  • DOI:
  • 发表时间:
    2004
  • 期刊:
  • 影响因子:
    0
  • 作者:
    星野慶子;茂木健司;根岸明秀
  • 通讯作者:
    根岸明秀
石原宏一, 根岸明秀, 茂木健司, 他: "知的障害者に対する全身麻酔下の治療経験"群馬県歯科医学会雑誌. 7. 29-34 (2003)
Koichi Ishihara、Akihide Negishi、Kenji Mogi 等:“全身麻醉下治疗智力障碍患者的经验”群马牙科协会杂志 7. 29-34 (2003)。
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    0
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NEGISHI Akihide其他文献

NEGISHI Akihide的其他文献

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{{ truncateString('NEGISHI Akihide', 18)}}的其他基金

INVESTIGATION OF THE TUMOR SUPPRESSOR GENES INVOLVED IN THE CARCINOGENESIS OF ORAL SQUAMOUS CELL CARCINOMA BASED ON THE GENETIC COMPLEMENT.
基于遗传互补的口腔鳞状细胞癌癌变抑癌基因研究。
  • 批准号:
    11671980
  • 财政年份:
    1999
  • 资助金额:
    $ 5.89万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
ROLE OF LOSS OF THE SHORT ARM OF CHROMOSOME 3 IN HUMAN ORAL SQUAMOUS CELL CARCINIGENESIS
3号染色体短臂缺失在人类口腔鳞状细胞癌变中的作用
  • 批准号:
    09672038
  • 财政年份:
    1997
  • 资助金额:
    $ 5.89万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Development of Treatment for Bone Defects in Maxilla Using Teflon Membran and the Analysis of Factors Promoting Maxillary Bone Regeneration
聚四氟乙烯膜治疗上颌骨骨缺损的进展及促进上颌骨再生的因素分析
  • 批准号:
    07672161
  • 财政年份:
    1995
  • 资助金额:
    $ 5.89万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)

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Development of a preoperative MRI radiomics model to predict sentinel lymph node metastasis in patients with cN0 breast cancer
开发术前 MRI 放射组学模型来预测 cN0 乳腺癌患者前哨淋巴结转移
  • 批准号:
    23K14916
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The relevance of the microenvironment and cancer metastasis of the sentinel lymph node
前哨淋巴结微环境与癌症转移的相关性
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    18K07241
  • 财政年份:
    2018
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    Grant-in-Aid for Scientific Research (C)
Development of non-invasive sentinel lymph node metastasis diagnosis and treatment by applying photodynamic therapy
光动力疗法无创前哨淋巴结转移诊断与治疗的进展
  • 批准号:
    18K08599
  • 财政年份:
    2018
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    $ 5.89万
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    Grant-in-Aid for Scientific Research (C)
Development of prediction model for sentinel lymph node metastasis by means of microRNA expression analysis
通过microRNA表达分析建立前哨淋巴结转移预测模型
  • 批准号:
    18K08569
  • 财政年份:
    2018
  • 资助金额:
    $ 5.89万
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    Grant-in-Aid for Scientific Research (C)
Intraoperative diagnostic system for the metastasis of sentinel lymph node using the genetic technique
利用基因技术诊断前哨淋巴结转移的术中系统
  • 批准号:
    21592200
  • 财政年份:
    2009
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    $ 5.89万
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    Grant-in-Aid for Scientific Research (C)
Sentinel lymph node metastasis imaging by using nanoparticle carriers in an animal study
在动物研究中使用纳米颗粒载体进行前哨淋巴结转移成像
  • 批准号:
    21592565
  • 财政年份:
    2009
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    $ 5.89万
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Basic and clinical research for evaluating micro-environmental changes in sentinel lymph node produced by micro-metastasis of carcinoma cell.
评估癌细胞微转移引起的前哨淋巴结微环境变化的基础与临床研究。
  • 批准号:
    19209044
  • 财政年份:
    2007
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Investigation of contrast ultrasound imaging with microbubble contrast agents for diagnosis of sentinel lymph node metastasis using esophageal cancer animal model
食管癌动物模型微泡造影剂超声造影诊断前哨淋巴结转移的研究
  • 批准号:
    17300175
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    2005
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    $ 5.89万
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    Grant-in-Aid for Scientific Research (B)
ASSESSING METASTASIS/RELAPSE IN SENTINEL LYMPH NODE DISSECTION MELANOMA PATIENTS
评估前哨淋巴结切除黑色素瘤患者的转移/复发
  • 批准号:
    6563795
  • 财政年份:
    2002
  • 资助金额:
    $ 5.89万
  • 项目类别:
In vivo diagnostic method of metastasis in the sentinel lymph node using tumor-avid radionuclide
使用肿瘤亲和放射性核素诊断前哨淋巴结转移的体内方法
  • 批准号:
    13670966
  • 财政年份:
    2001
  • 资助金额:
    $ 5.89万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
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