In vivo diagnostic method of metastasis in the sentinel lymph node using tumor-avid radionuclide

使用肿瘤亲和放射性核素诊断前哨淋巴结转移的体内方法

• 批准号: 13670966
• 负责人: FUJII Hirofumi
• 金额: $ 1.66万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13670966/
• 关键词: sentinel node; tumor; radionuclide; colloid particle; gallium; thallium; RI; MIBI; FDG; 放射性同位元素; 腫瘍親和性分子; シンチグラフィ

1) The transportation of tumor-avid radionuclide into the lymphatic system. The transportation of radionuclide into the lymphatic system was evaluated for the case who experienced the leakage of injected radionuclide. The visualized ratio of axillary nodes was low. These results indicated that tumor-avid radionuclides simply injected were poorly moved into sentinel nodes2) The size of colloid particles.Sentinel nodes were better visualized when small-sized tin colloid was administered than when routinely labeled tin colloid.3) Retention of tumor-avid radionuclide in the SLN The binding capacity of tumor-avid radionuclide Ga-67 and T1-201 to radioactive colloids were examined. However, these nuclides showed poor binding capacity to radioactive colloids.4) Imaging method with high sensitivity for sentinel nodesSome methods those could improve the contrast of SLNs to the background activity. But it was insufficient to detect micrometastatic lesions.5) Portable gamma camera Portable gamma camera with semiconductor detectors could improve the contrast, but sensitivity was little improved because collimator could not be omitted.

1)亲肿瘤放射性核素向淋巴系统的转运。对发生放射性核素渗漏的病例，评价放射性核素向淋巴系统的转运情况。腋窝淋巴结显示率低。这些结果表明，单纯注射的亲肿瘤放射性核素很难进入前哨淋巴结; 2）胶体颗粒的大小，小颗粒的锡胶体比常规标记的锡胶体能更好地显示前哨淋巴结; 3）亲肿瘤放射性核素在前哨淋巴结中的滞留检测亲肿瘤放射性核素Ga-67和T1-201与放射性胶体的结合能力。但这些核素与放射性胶体的结合能力较差。4）前哨淋巴结的高灵敏度成像方法提高前哨淋巴结与本底放射性的对比度。5）便携式γ照相机便携式γ照相机采用半导体探测器可以提高对比度，但由于不能省略准直器，灵敏度提高不大。

项目成果

Sentinel node detection.

哨兵节点检测。

• 发表时间: 2001
• 期刊: Jpn J Clin Radiol 46
• 作者: Fujii H;et al
• 通讯作者: et al

Sentinel node検索の意義と方法

Sentinel节点搜索的意义及方法

• 发表时间: 2001
• 期刊: 臨床放射線 46
• 作者: 藤井博史;他
• 通讯作者: 他

センチネルリンパ節イメージングのためのコントラスト強調

前哨淋巴结成像的对比增强

• 发表时间: 2001
• 期刊: 核医学 38
• 作者: 尾川浩一;藤井博史;他
• 通讯作者: 他

Contrast enhancement for sentinel lymph node imaging.

前哨淋巴结成像的对比增强。

• 发表时间: 2001
• 期刊: Jpn J Nucl Med 38
• 作者: Ogawa K;Fujii H;et al
• 通讯作者: et al

藤井 博史: "腫瘍のFDG PET肺癌"臨床画像. 17(5). 548-555 (2001)

Hiroshi Fujii：“肿瘤肺癌的 FDG PET”临床影像 17(5) (2001)。