Basic and clinical research for evaluating micro-environmental changes in sentinel lymph node produced by micro-metastasis of carcinoma cell.

(1)我们在AJP(Cell Physiology，295：C1123-C1132,2008)上报道了人乳腺癌细胞株MDA-MB-231产生了ATP介导的ICAM-1依赖的促进癌细胞与人内皮细胞附着的作用。(2)我们在癌症科学(100：419-428,2009)上报道了趋化因子CCL2促进了ICAM-1介导的癌细胞与人淋巴管内皮细胞的相互作用。(3)我们在AJP(Cell Physiology，298：C647-C655,2010)中报道了剪应力诱导的ATP介导的人淋巴管内皮细胞内皮细胞组成型一氧化氮合酶的表达。

(1) We reported in AJP (Cell Physiology, 295 : C1123-C1132, 2008) that human breast cancer cell line, MDA-MB-231 has produced ATP-mediated ICAM-1-dependent facilitation of the attachment of carcinoma cells to human endothelial cells.(2) We reported in Cancer Science (100 : 419-428, 2009) that chemokine CCL2 has facilitated ICAM-1-mediated interactions of Cancer Cells to human lymphatic endothelial cells.(3) We reported in AJP (Cell Physiology, 298 : C647-C655, 2010) that shear stress-induced ATP-mediated endothelial constitutive nitric oxide synthase expression in human lymphatic endothelial cells.