Molecular Biological Studies on Relationships between Changes in Renal Tubular Transporter Gene Expressions and Deterioration of Drug Excretory Functions in Renal Diseases

点击翻译按钮获取中文摘要

The proximal tubules of kidney play a pivotal role in limiting or preventing toxicity by secreting organic anions and cations into urine. Organic ion transporter family(SLC22A) appeared to mediate renal secretion of these molecules. Organic anion transporters, OAT-K1 and OAT-K2 could serve as multispecific transporters, mediating transport of a wide variety of endogenous substances and xenobiotics. The levels of urinary excretion of dmetidine was reduced under cronic renal failure(CRF) partiy due to the reduced expression of rOCT2, and the lowered plasma level of testosterone was suggested to be responsible for the depressed rOCT2 expression in CRF. hOAT3 was suggested to play an important role for anionic drug secretion in patients with renal diseases and that the expression levels of drug transporters may be related to the alteration of renal drug secretion.