Novel strategy for development of suppressive drugs for kidney disease based on inhibition of metabolic production of uremic toxins

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This study was aimed to explore inhibitors of hepatic production of indoxyl sulfate based on uremic toxins which are involved in renal dysfuntion and kidney injury with uremia. By using the screening system for indoxyl sulfate production inhibitors, we found that polyphenolic compounds had potent inhibitory effects on hepatic indoxyl sulfate production. Administration of these polyphenols to rats with acute kidney injury ameliorated the disturbed renal function, suggesting that these approaches could be a useful strategy to develop therapeutic drugs for kidney injuries and/or dieases.