Effect of physical activity on systemic arterial compliance: a cross-sectional and a longitudinal study in older humans

体力活动对全身动脉顺应性的影响：针对老年人的横断面和纵向研究

• 批准号: 14380008
• 负责人: MATSUDA Mitsuo
• 金额: $ 7.68万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14380008/
• 关键词: older human; elderly human; arterial compliance; physical activity; exercise training; vascular endothelial function; aorta; 運動トレーニンゲ

The purpose of the present study was to investigate the effect of daily physical activity on systemic arterial compliance (SAC) in older humans. The products of this study are as follows. First, SAC might be a determinant of cardiorespiratory fitness (ventilatory threshold : VT), and meanwhile, endurance exercise training could improve both arterial compliance and VT in older humans. Second, an increase in daily physical activity could improve the age-induced reduction of arterial compliance and the age-related rise of systolic blood pressure in older humans. However, there was a limitation in the effect of physical activity on SAC, i.e., SAC might not exceed a certain level regardless of an increase in physical activity. Third, aerobic exercise training caused a decrease in plasma endothelin-1 (a potent vasoconstrictor peptide) level and an increased in plasma nitric oxide (a potent vasodilator substance) level (measured as nitrite/nitrate) in older humans. The gene and protein expression of endothelial NO synthase (eNOS) in the aorta of rat was decreased by aging, and the expression was increased by aerobic exercise training

本研究的目的是调查日常体力活动对老年人全身动脉顺应性（SAC）的影响。本研究的成果如下。首先，SAC可能是心肺适能的决定因素（舒张阈值：VT），同时，耐力运动训练可以改善老年人的动脉顺应性和VT。其次，增加日常体力活动可以改善老年人年龄引起的动脉顺应性降低和收缩压与年龄相关的升高。然而，体力活动对SAC的影响是有限的，即，SAC可能不会超过一定的水平，无论身体活动是否增加。第三，有氧运动训练导致老年人血浆内皮素-1（一种有效的血管收缩肽）水平降低，血浆一氧化氮（一种有效的血管扩张物质）水平升高（以亚硝酸盐/硝酸盐计）。大鼠主动脉内皮型一氧化氮合酶（eNOS）基因和蛋白表达随增龄而降低，有氧运动训练使其表达增加

项目成果

Takeshi Otsuki, et al.: "Simple and noninvasive recording method of arterial blood pressure waveform for estimate of systemic arterial compliance : validation of using peripheral arterial blood pressure waveform in young adults"Jpn.J.Clin.Sports Med.. 12.

Takeshi Otsuki 等人：“用于估计全身动脉顺应性的简单且无创的动脉血压波形记录方法：在年轻人中使用外周动脉血压波形的验证”Jpn.J.Clin.Sports Med. 12。

大槻毅: "中高齢女性の全身持久性体力に及ぼす動脈系コンプライアスの影響-横断的および縦断的研究-"日本臨床スポーツ医学会誌. 11. 543-551 (2003)

Takeshi Otsuki：“动脉系统顺应性对中老年女性全身耐力体能的影响 - 横断面和纵向研究 -”日本临床运动医学会杂志 11. 543-551 (2003)。

Takumi Tanabe, et al.: "Effect of physical activity on systolic blood pressure in elderly humans : special reference to systemic arterial compliance"Jpn.J.Phys.Fitness Sports Med.. 52 Suppl. 167-176 (2003)

Takumi Tanabe 等人：“体力活动对老年人收缩压的影响：特别参考全身动脉顺应性”Jpn.J.Phys.Fitness Sports Med.. 52 Suppl.

大槻毅: "動脈系コンプライアンスを評価するための簡便で非侵襲的な動脈血圧波形の記録法:若年成人において末梢動脈血圧波形を用いる方法の妥当性"日本臨床スポーツ医学会誌. 12. 41-48 (2004)

Takeshi Otsuki：“一种简单且无创的动脉血压波形记录方法，用于评估动脉系统顺应性：在年轻人中使用外周动脉血压波形的有效性”日本临床运动医学会杂志 12. 41-48。 (2004)

Tanabe et al.: "Exercise training improves aging-induced decrease in eNOS expression of the aorta."Acta Physiologica Scandinavica. 178. 3-10 (2003)

Tanabe 等人：“运动训练可以改善衰老引起的主动脉 eNOS 表达的减少。”Acta Physiologica Scandinavica。