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RETRIEVAL OF BIOMARKER FOR PSYCHOLOGICAL-STRESS AND REGULATION OF EMOTION BU FOOD COMPONENTS

心理压力生物标志物的检索和情绪调节 BU 食品成分

基本信息

批准号：
15380095
负责人：
YOKOGOSHI Hidehiko
金额：
$ 10.24万
依托单位：
THE UNIVERSITY OF SHIZUOKA
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2003
资助国家：
日本
起止时间：
2003 至 2004
项目状态：
已结题

项目摘要

WE EXAMINED THE RELATIONSHIPS BETWEEN NUTRITION, NEUROTRANSMITTERS AND BRAIN FUNCTION UNDER THE LOADING OF SOME KINDS OF STRESSOR. HOWEVER, AT FIRST, WE STUDED THE EFFECT OF SOME FOOD COMPONENTS FOR BRAIN NEUROTRANSMITTERS.1. MYCOLEPTODONOIDES AITCHISONII:IN THE CENTRAL NERVOUS SYSTEM, IT IS SUGGESTED THAT CHOLINERGIC NEURON DEFICIENCY MAY BE ONE OF THE MAIN CAUSE OF ALZHEIMER'S DISEASE-TYPE DEMENTIA AND NERVE GROWTH FACTOR (NGF) AFFECTS THE GROWTH, MAINTENANCE AND PLASTICITY OF CHOLINERGIC NEURONS IN BASAL FOREBRAIN. NGF IS A NEUROTROPHIC FACTOR THAT HAS IMPORTANT FUNCTIONS IN BOTH GROWTH AND MAINTENANCE OF PERIPHERAL SYMPATHETIC NEURONS. FURTHERMORE, NGF PLAYS AN IMPORTANT ROLE IN BRAIN DEVELOPMENT IN INFANCY. VARIOUS KINDS OF NUTRIENTS AND FOOD COMPONENTS, DEMONSTRATED THE EFFECTS ON NEUROTRANSMITTERS SUCH AS CATECHOLAMINES AND INDOLEAMINES. FOR EXAMPLE, FOOD CONTAINING TYROSINE OR ASPARTAME RAISED THE LEVELS OF CATECHOLAMINES OR INDOLEAMINES IN RAT BRAIN, RESPECTIVELY. IN ADDITION, … More RECENT OUR PAPER DEMONSTRATED THAT AN AQUEOUS EXTRACT OF MYCOLEPTODONOIDES AITCHISONII HAS BEEN SHOWN TO LOWER BLOOD PRESSURE IN SPONTANEOUSLY HYPERTENSIVE RATS (SHR). THE, WE EXAMINE THE EFFECT OF MYCOLEPTODONOIDES AITCHISONII ON BRAIN NEUROTRANSMITTEERS AND SOME KINDS OF BEHAVIOR. ENHANCING EFFECT OF MYCOLEPTODONOIDES AITCHISONII ON SYNTHESIS OF NERVE GROWTH FACTOR AND RELEASING DOPAMINE IN THE RAT BRAIN. MYCOLEPTODONOIDES AITCHISONII AFFECTS BRAIN NERVE GROWTH FACTOR CONCENTRATION IN NEWBORN RATS. CONDUCTOR COMPOUNDS OF PHENYLPENTANE IN MYCOLEPTODONOIDES AITCHISONII MYCELIUM ENHANCE THE RLEASE OF DOPAMINE FROM RAT BRAIN STRIATUM SLICES.2. THEANINE OF GREEN TEA EXTRACTS:THEANINE, γ-GLUTAMYLETHYL AMIDE, IS THE MOST ABUNDANT AMINO ACIDS IN JAPANESE GREEN TEA EXTRACT. BY USING THE BRAIN MICRODIALYSIS TECHNIQUE, THE ANINE CAUSED A SIGNIFICANT INCREASE OF DOPAMINE RELEASE IN RAT STRIATUM. THEREFORE, WE EXAMINED THE MECHANISM OF THEANINE ON DOPAMINE RELEASE IN SYNAPUS BY DETERMINING SOME TRANSPORTERS OR RECEPTORS.3. CACAO:CACAO WHICH IS THE MAIN COMPONENTS OF CHOCOLATE OR COCOA CONTAINES MANY PYSIOLOGICAL FUNCTIONAL COMPONENTS SUCH AS POLYPHENOL, THEOBROMINE, OR CAFFEINE. WE EXAMINED THE EFFECT OF CACAO ON BRAIN NEUROTRANSMITTERS AND EMOTIONS. WHEN RATS FED CACAO-CONTAINING DIETS OR WERE INTRAGASTRICALLY INTUBATED CACAO-PASTE, BRAIN DOPAMINE IN SOME BRAIN REGIONS WAS SIGNIFICANTLY INCREASED. THEREFORE, WE INVESTIGATED SOME EMOTIONS BY USING THE ELEVATED PLUS-MAZE TEST OR ELEVATED T-MAZE TEST. Less

本文探讨了几种应激负荷下营养、神经递质与脑功能的关系。然而，我们首先研究了某些食物成分对脑神经递质的影响。在中枢神经系统中，胆碱能神经元缺乏可能是阿尔茨海默病型痴呆的主要原因之一，神经生长因子（NGF）影响基底前脑胆碱能神经元的生长、维持和可塑性。神经生长因子是一种神经营养因子，对周围交感神经元的生长和维持具有重要作用。此外，NGF在婴儿期脑发育中起重要作用。各种营养素和食物成分，证明了对神经递质如儿茶酚胺和吲哚胺的影响。例如，含有酪氨酸或天冬氨酸的食物分别提高了大鼠脑中的儿茶酚胺或吲哚胺的水平。此外， ...更多信息最近我们的论文证明，一种水提取物Mycoleptodonoides Aitchisonii已被证明降低血压自发性高血压大鼠（SHR）。同时，我们观察了艾氏支原体对脑神经递质和某些行为的影响。艾氏菌对大鼠脑内神经生长因子合成和多巴胺释放的促进作用。艾氏支原体对新生大鼠脑神经生长因子浓度的影响艾氏菌菌丝体中的苯戊烷类导体化合物促进多巴胺从大鼠脑片中的释放.绿色提取物的茶氨酸：茶氨酸，γ-谷氨酰乙基酰胺，是日本绿色提取物中最丰富的氨基酸。用脑微扩张技术观察到，盐酸阿托伐他汀可使大鼠脑多巴胺释放量显著增加。因此，我们通过对一些转运体或受体的研究，探讨了茶氨酸对突触多巴胺释放的作用机制.可可粉：可可粉是巧克力或可可的主要成分，含有多种生理功能成分，如多酚、溴素或咖啡因。本实验观察了可可对脑神经递质和情绪的影响。当大鼠喂食含可可的饲料或胃内插管可可糊时，某些脑区的脑多巴胺显著增加。因此，我们用高架十字迷宫或高架T迷宫测试对一些情绪进行了测试。少