Neurodegenerative mechanism on ribotoxic stress and apoptosis

神经原纤维缠结（nft）是阿尔茨海默病（AD）的神经病理学标志，异常过度磷酸化的tau是nft的主要蛋白质成分。根据我们前期对tau蛋白磷酸化调控的研究，推测内在抗凋亡因子参与了AD神经退行性过程。XIAP（X染色体连锁的凋亡抑制剂）是一种内在的抗凋亡蛋白。首先，在AD脑中观察到XIAP的表达高于对照组。其次，只有当第一个蛋氨酸被删除时，才观察到XIAP与n端tau序列的结合。这些结果提示XIAP可能参与阿尔茨海默病或牛头病的神经退行性过程，该过程进展缓慢。

Neurofibrillary tangles(NFTs) are neuropathological hallmarks of Alzheimer disease(AD) and abnormally hyperphosphorylated tau is the major protein component of NFTs. According to our previous studies on the regulation of phosphorylation of tau protein, an involvement of intrinsic anti-apoptotic factor in neurodegenerative process in AD, is speculated. XIAP(X chromosome-linked inhibitor of apoptosis), one of intrinsic anti-apoptotic proteins, was investigated in this study. First, higher expression of XIAP was observed in AD brain than in control brain. Second, the binding of XIAP with N-terminal tau sequence was observed only when the first methionine was deleted. These results suggest that XIAP might be involved in neurodegenerative process of AD or tauopathy, that is slowly progressive.