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Genetic study on Alzheimer Disease

Genetic study on Alzheimer Disease
阿尔茨海默病的基因研究
批准号:
17019043
负责人:
TAKEDA Masatoshi
金额:
$54.85万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

项目摘要

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中文摘要
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英文摘要
We identified several candidate Alzheimer related genes using different approaches. DYRK1A was identified by genome scan in chromosome 21 and confirmed the importance by expression and functional analysis. Functional and expression analysis on DNM2, another AD candidate gene, was also performed. Expression analysis found PPP2R2B and confirmed by association study. We also searched amyloid modifier genes in AD model mice.
期刊论文(130)
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科研奖励(0)
会议论文
DOI: 10.1159/000203891
发表时间: 2009-02
期刊: Dementia and Geriatric Cognitive Disorders
影响因子: 2.4
作者: [N. Shibata;T. Ohnuma;H. Baba;H. Arai]
通讯作者: N. Shibata;T. Ohnuma;H. Baba;H. Arai
DOI: 10.1016/j.neulet.2009.06.014
发表时间: 2009-09-11
期刊: NEUROSCIENCE LETTERS
影响因子: 2.5
作者: [Kimura, Ryo, Yamamoto, Mitsuko, Takeda, Masatoshi]
通讯作者: Takeda, Masatoshi
DOI: 10.1159/000235943
发表时间: 2009-01-01
期刊: EUROPEAN NEUROLOGY
影响因子: 2.4
作者: [Suto, Yutaka, Nakayasu, Hiroyuki, Nakashima, Kenji]
通讯作者: Nakashima, Kenji
DOI: 10.1016/j.neurobiolaging.2004.09.004
发表时间: 2005-07-01
期刊: NEUROBIOLOGY OF AGING
影响因子: 4.2
作者: [Shibata, N, Ohnuma, T, Arai, H]
通讯作者: Arai, H
104
    Synthesis of fine-structured CaB6 using nano crystals grown by low-temperature process for improvement of its thermoelectric properties
    • 批准号:
      18K04680
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $2.83万
    • 财政年份:
      2018
    • 负责人:
      TAKEDA Masatoshi
    • 依托单位:
    The analysis of regulatory mechanisms of degradation/aggregation of abnormally accumulated protein in fontotemporal dementia brain.
    • 批准号:
      24390283
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.56万
    • 财政年份:
      2012
    • 负责人:
      TAKEDA Masatoshi
    • 依托单位:
    The mechanisms of aggregation, accumulation and degradation of the genetically causative protein related to familial dementia diseases
    • 批准号:
      21390333
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $11.56万
    • 财政年份:
      2009
    • 负责人:
      TAKEDA Masatoshi
    • 依托单位:
    Influence of defect on thermoelectric properties of metal-hexaborides
    • 批准号:
      20560613
    • 项目类别:
      Grant-in-Aid for Scientific Research (C)
    • 资助金额:
      $3.0万
    • 财政年份:
      2008
    • 负责人:
      TAKEDA Masatoshi
    • 依托单位:
    海外基金