Elucidation of pathogenesis and novel therapeutics for refractory leukemias

阐明难治性白血病的发病机制和新疗法

• 批准号: 18H04052
• 负责人: KUROKAWA MINEO
• 金额: $ 28.45万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2018
• 资助国家: 日本
• 起止时间: 2018-04-01 至 2021-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-18H04052/
• 关键词: 急性骨髄性白血病; 難治性白血病; 転写因子

项目成果

Posterior Reversible Encephalopathy Syndrome Concurrent with Human Herpesvirus-6B Encephalitis after Allogeneic Hematopoietic Stem Cell Transplantation.

同种异体造血干细胞移植后并发人疱疹病毒 6B 脑炎的可逆性后部脑病综合征。

• DOI: 10.1016/j.jiac.2019.07.016
• 发表时间: 2020
• 期刊: Journal of Infection and Chemotherapy
• 影响因子: 2.2
• 作者: Ito Y;Toyama K;Honda A;Nakazaki K;Arai S;and Kurokawa M.
• 通讯作者: and Kurokawa M.

A Synthetic Lethality-based Approach Identified EED and BRD4 as Critical Survival Factors in Acute Myeloid Leukemia with Monosomy 7

基于合成致死率的方法将 EED 和 BRD4 确定为 7 号单体急性髓系白血病的关键生存因素

• 发表时间: 2019
• 作者: Kensuke Matsuda;Yuki Kagoya;Sho Yamazaki;Masashi Miyauchi;Mineo Kurokawa
• 通讯作者: Mineo Kurokawa

GFI1 Is a Downstream Target of EVI1 in Normal Hematopoiesis

GFI1 是正常造血过程中 EVI1 的下游靶标

• 发表时间: 2020
• 作者: Akira Chiba;Yosuke Masamoto;Hideaki Mizuno;Mineo Kurokawa
• 通讯作者: Mineo Kurokawa

ACTIVATED PENTOSE PHOSPHATE PATHWAY MEDIATED BY FBP1 UPREGULATION SUPPORTS PROGRESSION OF ACUTE MYELOID LEUKEMIA WITH HIGH EVI1 EXPRESSION

FBP1 上调介导的激活戊糖磷酸途径支持高 EVI1 表达的急性髓系白血病的进展

• 发表时间: 2020
• 作者: Hideaki Mizuno;Yuki Kagoya;Junji Koya;Yosuke Masamoto;Mineo Kurokawa
• 通讯作者: Mineo Kurokawa

Calcium/Calmodulin Dependent Protein Kinase 2 Gamma Is Identified As a Potential Therapeutic Target of Myelofibrosis Using Disease-Specific Induced Pluripotent Stem Cells

利用疾病特异性诱导多能干细胞，钙/钙调蛋白依赖性蛋白激酶 2 Gamma 被确定为骨髓纤维化的潜在治疗靶点

• 发表时间: 2018
• 作者: Masashi Miyauchi;Ken Sasaki;Kazuki Taoka;Yosuke Masamoto;Sho Yamazaki;Shunya Arai and Mineo Kurokawa
• 通讯作者: Shunya Arai and Mineo Kurokawa