Identification of phospholipase activity of PRMT8 and its biological significance

在蛋白精氨酸甲基转移酶家族中，PRMT1占细胞内精氨酸甲基转移酶总活性的85%以上，定位于细胞质和细胞核。虽然PRMT8与PRMT1有83%的氨基酸同源性，但其生物学意义和底物尚不清楚。在本研究中，我们试图检测PRMT8的酶活性及其细胞功能。

Among the family of protein arginine methyltransferases, PRMT1 accounts for over 85% of the total arginine methyltransferase activities in cells, and it is localized in the cytoplasm and nucleus. Although PRMT8 that has 83% amino acid homology to PRMT1, its biological significance and substrate remain unclear. In the present study, we tried to examine the enzymatic activity of PRMT8 and its cellular function.