Feto-maternal network on pregnancy-induced hypertension

关于妊娠高血压综合征的胎儿-母体网络

• 批准号: 17108004
• 负责人: FUKAMIZU Akiyoshi
• 金额: $ 69.31万
• 依托单位: University of Tsukuba
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17108004/
• 关键词: 妊娠中毒症; 妊娠高血圧症候群; 母胎間ネットワーク; レニン-アンジオテンシン系; 子宮内発育遅延; トランスジェニックマウス; アペリン-APJ受容体; 胎児-胎盤系; 妊娠高血圧; 胎児発育遅延; 母体; 摘出血管; 血管収縮; 血管弛緩; 胎盤; レニンーアンジオテンシン系; 母胎; アポトーシス; マイクロアレー; 少子高齢化; 出産

In the present study, using the model mice associated with hypertension during pregnancy (PAH) developed in our laboratory, we have investigated (1) the pathogenesis of pregnancy-associated hypertension and the feto-maternal network, (2) the development of intrauterine growth retardation (IUGR) and its molecular mechanism, and (3) the possible involvement of a new cardiovascular system, APJ, in the pathogenesis of hypertension during pregnancy. In PAH mice, the dysfunction of endothelial cells in the placenta as the core of feto-maternal network known to play an integral part of pregnancy was observed, suggesting the development of IUGR.All pups associated with IUGR born from hypertensive mothers showed cardiac hypertrophy, anemia like phenotypes, and atrophy of many organs other than the heart, and died one day after birth. Furthermore, PAH mice showed the similar phenotypes to human HELLP syndrome. Moreover, it was suggested that APJ was involved in the exacerbation of proteinuria induced in PAH mice at the late pregnancy.

在本研究中，使用与怀孕期间高血压（PAH）相关的模型小鼠，我们已经研究了（1）与妊娠相关高血压和feto-副作用网络的发病机理，（2）在宫内内生长迟缓（IUGR）的发展（IUGR）及其分子机制，以及（3）在可能涉及的新型系统中，在新的系统中，（3）怀孕。 In PAH mice, the dysfunction of endothelial cells in the placenta as the core of feto-maternal network known to play an integral part of pregnancy was observed, suggesting the development of IUGR.All pups associated with IUGR born from hypertensive mothers showed cardiac hypertrophy, anemia like phenotypes, and atrophy of many organs other than the heart, and died one day after birth.此外，PAH小鼠表现出与人Hellp综合征相似的表型。此外，有人提出APJ参与了妊娠晚期PAH小鼠诱导的蛋白尿的加剧。

项目成果

Renin inhibition reduces hypercholesterolemia-induced atherosclerosis in mice

• DOI: 10.1172/jci32970
• 发表时间: 2008-03-01
• 期刊: JOURNAL OF CLINICAL INVESTIGATION
• 影响因子: 15.9
• 作者: Lu, Hong;Rateri, Debra L.;Daugherty, Alan
• 通讯作者: Daugherty, Alan

Attenuation of diet-induced weight gain and adiposity through increased energy expenditure in mice lacking angiotensin II type 1a receptor

• DOI: 10.1210/en.2005-0003
• 发表时间: 2005-08-01
• 期刊: ENDOCRINOLOGY
• 影响因子: 4.8
• 作者: Kouyama, R;Suganami, T;Ogawa, Y
• 通讯作者: Ogawa, Y

Requirement of apelin-apelin receptor system for oxidative stress-linked atherosclerosis

• DOI: 10.2353/ajpath.2007.070471
• 发表时间: 2007-11-01
• 期刊: AMERICAN JOURNAL OF PATHOLOGY
• 影响因子: 6
• 作者: Hashimoto, Tatsuo;Kihara, Minoru;Umemura, Satoshi
• 通讯作者: Umemura, Satoshi

Reduced angiogenesis and delay in wound healing in angiotensin II type 1a receptor-deficient mice

• DOI: 10.1016/j.biopha.2009.01.001
• 发表时间: 2009-11-01
• 期刊: BIOMEDICINE & PHARMACOTHERAPY
• 影响因子: 7.5
• 作者: Kurosaka, Maya;Suzuki, Tatsunori;Majima, Masataka
• 通讯作者: Majima, Masataka

妊娠高血圧マウスの心臓病態におけるAT1シグナル阻害による改善効果

AT1信号抑制对妊娠高血压小鼠心肌病理的改善作用

• 发表时间: 2009
• 作者: 小泉昭夫;箸方宏州;劉万洋;井上佳代子;峰晴陽平;山田茂樹;松浦範夫;井上純子;竹中勝信;人見敏明;原田浩二;K.-I.Yoshikawa;竹立新人;中村匠子
• 通讯作者: 中村匠子