Imaging study of redox status in vivo in oxidative stress-associateddisease model animals using OMRI

新的成像技术Overhauser-MRI(OMRI)可以基于动态核极化(DNP)实现动物组织氧化还原状态的可视化，与电子自旋共振成像(ESRI)相比，具有更高的空间分辨率。在这项研究中，我们将OMRI应用于各种氧化性疾病模型，如多巴胺能神经毒性、吲哚美辛诱导的胃损伤和精神分裂症。作为一种非侵入性技术，结合OMRI成像和氧化还原探针监测组织的氧化还原状态可能有助于获取有关器官功能的有价值的信息，用于氧化性疾病的临床前和临床研究。

Novel imaging technique Overhauser-MRI (OMRI) enables visualization of tissue redox status in animals based on dynamic nuclear polarization (DNP) with higher spatial resolution compared with electron spin resona nce imaging (ESRI). In this study, we applied OMRI to various oxidative disease models such as dopaminergic neurotoxicity , indomethacin-induced gastric damage and schizophrenic disorder. As a noninvasive technique, combining OMRI imaging with redox probes to monitor tissue redox status may be useful in acquiring valuable information regarding organ function for preclinical and clinical studies of oxidative diseases.