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Study of Free Radicals in Tissue and Transdermal Drug Delivery by using in vivo ESR with Spectral-Spatial ESR-CT Imaging

利用体内 ESR 和光谱空间 ESR-CT 成像研究组织和透皮药物递送中的自由基

基本信息

批准号：
03671032
负责人：
UTSUMI Hideo
金额：
$ 1.34万
依托单位：
Showa University
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1991
资助国家：
日本
起止时间：
1991 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-03671032/
关键词：
ESR Imaging Free Radical Active Oxygens CT CT イメージングスペクトル逆投影法反復法ラジカル

项目摘要

The several techniques for ESR imaging have been developed. The conventional methods for ESR-CT are based on the assumption that only one spectralcomponetn is existing in all space observed. No image can be constructed if more than two signal componets are coexisting in different part. In order to accomplish the image construction from plural signal components, we tried to connect spectral-spatial imaging technique with CT imaging.1. We report the ESR-CT imaging by the phantom involving two radical species giving different signals. Spectral-spatial images obtained on four derections in X-Z plane. The spatial information was separated from the spectral-spatial images by each radical component. Two separation methods were compared. In one method, separation could not be complete. The border was broadened in other method. Two sets of CT images of two signal components were reconstructured. CT images have good agreement with arrangement of phantom.2. The phantom involving liposomes which encapsulated nitroxide (150 mM) and free nitroxide (3.3mM) was made. We obtained the ESR-CT imaging by L-band ESR.CT images have good agreement with the distribution of loposomes and free nitroxide.These results demonstrate the possibility of ESR-CT for the sample including plural signal components.

ESR成像的几种技术已经发展。传统的ESR-CT方法是基于在所有观测空间中只存在一个谱分量的假设。如果两个以上的信号分量共存于不同的部分，则不能构成图像。为了实现多信号分量的图像重建，我们尝试将频谱空间成像技术与CT成像技术相结合.我们报告的ESR-CT成像的幻影涉及两个自由基物种给出不同的信号。在X-Z平面内四个方向上获得的光谱-空间图像。空间信息从光谱-空间图像中分离出每个径向分量。对两种分离方法进行了比较。在一种方法中，分离不可能是完全的。边界是用其他方法扩大的。重建两组信号分量的CT图像。CT图像与体模的排列有很好的一致性.制备包含包封氮氧自由基（150 mM）和游离氮氧自由基（3.3 mM）的脂质体的体模。我们用L-带ESR获得了ESR-CT图像，CT图像与脂质体和游离氮氧自由基的分布有很好的一致性，这些结果证明了对含有多种信号成分的样品进行ESR-CT的可能性。