Analysis of mitochondrial functions in diseases
Analysis of mitochondrial functions in diseases
批准号:
22249018
负责人:
KANG Dongchon
金额:
$31.03万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2010
资助国家:
日本
项目状态:
已结题
起止时间:
2010 至 2012
中文摘要
(1)TFAM结合蛋白中的ERAL1和p32是线粒体核糖体有效形成所必需的,提示线粒体类核糖体在线粒体翻译中起重要作用。(2)建立了线粒体DNA突变细胞代谢组学分析系统。(3)发现与代谢综合征和阿尔茨海默病相关的单核苷酸多态。
英文摘要
(1) ERAL1 and p32 of TFAM-binding proteins were essential for efficient formation of mitochondrial ribosomes, suggesting contribution of mitochondrial nucleoids to mitochondrial translation. (2) A metabolomic analysis system of cells harboring mitochondrial DNA mutations was set up. (3) Single nucleotide polymorphisms related to metabolic syndrome and Alzheimer disease were found.
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The physiological role of mitophagy: new insights into phosphorylation events.
线粒体的生理作用:对磷酸化事件的新见解。
DOI:
10.1155/2012/354914
发表时间:
2012
期刊:
International journal of cell biology
影响因子:
--
作者:
[Hirota Y, Kang D, Kanki T]
通讯作者:
Kanki T
DOI:
10.1016/j.bbamcr.2010.04.008
发表时间:
2010-08-01
期刊:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
影响因子:
5.1
作者:
[Ruhanen, Heini, Borrie, Sarah, Yasukawa, Takehiro]
通讯作者:
Yasukawa, Takehiro
mtSSB may sequester UNG1 at mitochondrial ssDNA and delay uracil processing until the dsDNA conformation is restored
mtSSB 可能会在线粒体 ssDNA 上隔离 UNG1 并延迟尿嘧啶加工,直到 dsDNA 构象恢复
DOI:
--
发表时间:
2012
期刊:
DNA Repair (Amst)
影响因子:
--
作者:
[Wollen Steen, K., Doseth, B., M, P. W., Akbari, M., Kang, D., Falkenberg, M., Slupphaug, G.]
通讯作者:
G.
Mitochondrial Genomic Disintegrity and Age-Related Diseases
线粒体基因组断裂和年龄相关疾病
DOI:
--
发表时间:
2012
期刊:
Anti-Aging Medicine
影响因子:
--
作者:
[Kang, D.]
通讯作者:
D.
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[Kang, D]
通讯作者:
D
共 48 条
Mitochondrial DNA analysis for diabetes cohort study
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批准号:21659148
-
项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.24万
-
财政年份:2009
-
负责人:KANG Dongchon
-
依托单位:
Mitochondrial DNA disease and its diagnostic system
-
批准号:19209019
-
项目类别:Grant-in-Aid for Scientific Research (A)
-
资助金额:$32.28万
-
财政年份:2007
-
负责人:KANG Dongchon
-
依托单位:
Effect of mitochondrial transcription factor A (TFAM) on aging of mouse
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批准号:17390095
-
项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.41万
-
财政年份:2005
-
负责人:KANG Dongchon
-
依托单位:
Identification of human mitochondrial metabolome proteins
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批准号:15390106
-
项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$9.86万
-
财政年份:2003
-
负责人:KANG Dongchon
-
依托单位:
A role of Holliday structure in mitochondrial genome maintenance
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批准号:13670146
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.62万
-
财政年份:2001
-
负责人:KANG Dongchon
-
依托单位:
Inhibition of mitochondrial DNA replication by MPP+, a Parkinsonism-inducing toxin
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批准号:11670144
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项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$2.3万
-
财政年份:1999
-
负责人:KANG Dongchon
-
依托单位:
Analysis of oxidative damage of mitochondrial DNA
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批准号:09835009
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$1.92万
-
财政年份:1997
-
负责人:KANG Dongchon
-
依托单位:
海外基金