Mitochondrial DNA disease and its diagnostic system

线粒体DNA疾病及其诊断系统

• 批准号: 19209019
• 负责人: KANG Dongchon
• 金额: $ 32.28万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (A)
• 财政年份: 2007
• 资助国家: 日本
• 起止时间: 2007 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19209019/
• 关键词: ミトコンドリアDNA; 遺伝子診断; 活性酸素; 糖尿病; ミトコンドリア病; 遺伝子多型; 老化

The following three projects are integrated for further understanding of mitochondrial disease and for construction of its diagnostic system : (1) molecular mechanism of maintenance of mitochondrial DNA (mtDNA), (2) molecular diagnosis of mitochondrial disease, and (3) mtDNA analysis of somatic cells. Now we accept genetic tests of mitochondrial disease from all over Japan. During this period, we have shown that maintenance of mtDNA can delay natural aging process in TFAM-expressing transgenic mice. The mtDNA analysis of somatic cells is on going.

为了进一步了解线粒体疾病并构建其诊断系统，整合了以下三个项目：（1）线粒体DNA（mtDNA）维持的分子机制，（2）线粒体疾病的分子诊断，以及（3）体细胞的mtDNA分析。现在我们接受来自日本各地的线粒体疾病基因检测。在此期间，我们发现，在表达 TFAM 的转基因小鼠中，维持 mtDNA 可以延缓自然衰老过程。体细胞的线粒体DNA分析正在进行中。

项目成果

Clonal spread in Eastern Asia of ciprofloxacin-resistant Escherichia coli serogroup O25 strains, and associated virulence factors

• DOI: 10.1016/j.ijantimicag.2009.12.012
• 发表时间: 2010-05-01
• 期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
• 影响因子: 10.8
• 作者: Uchida, Yujiro;Mochimaru, Tomomi;Kang, Dongchon
• 通讯作者: Kang, Dongchon

Platelet contamination causes large cariation as well as overestimation of mitochomdrial DNA content of peripheral blood mononuclear cells

血小板污染导致大面积龋齿以及外周血单个核细胞线粒体DNA含量高估

• 发表时间: 2008
• 期刊: Annals of Clinical Biochemistry (In press)
• 作者: Urata;M.;et. al.
• 通讯作者: et. al.

Castration resistance of prostate cancer cells caused by castration-induced oxidative stress through Twist1 and androgen receptor overexpression

• DOI: 10.1038/onc.2009.322
• 发表时间: 2010-01-14
• 期刊: ONCOGENE
• 影响因子: 8
• 作者: Shiota, M.;Yokomizo, A.;Naito, S.
• 通讯作者: Naito, S.

Peroxisome proliferator-activated receptor gamma coactivator-1alpha interacts with the androgen receptor (AR) and promotes prostate cancer cell growth by activating the AR.

• DOI: 10.1210/me.2009-0302
• 发表时间: 2010
• 期刊: Molecular endocrinology
• 作者: M. Shiota;A. Yokomizo;Y. Tada;J. Inokuchi;K. Tatsugami;K. Kuroiwa;T. Uchiumi;N. Fujimoto;N. Seki;S. Naito

Decreased maternal protein S activity is associated with fetal growth restriction

• DOI: 10.1016/j.thromres.2008.01.016
• 发表时间: 2008-01-01
• 期刊: THROMBOSIS RESEARCH
• 影响因子: 7.5
• 作者: Hojo, Satoshi;Tsukimori, Kiyomi;Wake, Norio
• 通讯作者: Wake, Norio