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Mitochondrial DNA disease and its diagnostic system

Mitochondrial DNA disease and its diagnostic system
线粒体DNA疾病及其诊断系统
批准号:
19209019
负责人:
KANG Dongchon
金额:
$32.28万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (A)
财政年份:
2007
资助国家:
日本
项目状态:
已结题
起止时间:
2007 至 2009

项目摘要

项目成果

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中文摘要
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英文摘要
The following three projects are integrated for further understanding of mitochondrial disease and for construction of its diagnostic system : (1) molecular mechanism of maintenance of mitochondrial DNA (mtDNA), (2) molecular diagnosis of mitochondrial disease, and (3) mtDNA analysis of somatic cells. Now we accept genetic tests of mitochondrial disease from all over Japan. During this period, we have shown that maintenance of mtDNA can delay natural aging process in TFAM-expressing transgenic mice. The mtDNA analysis of somatic cells is on going.
期刊论文(49)
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会议论文
DOI: 10.1016/j.ijantimicag.2009.12.012
发表时间: 2010-05-01
期刊: INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS
影响因子: 10.8
作者: [Uchida, Yujiro, Mochimaru, Tomomi, Kang, Dongchon]
通讯作者: Kang, Dongchon
Platelet contamination causes large cariation as well as overestimation of mitochomdrial DNA content of peripheral blood mononuclear cells
血小板污染导致大面积龋齿以及外周血单个核细胞线粒体DNA含量高估
DOI: --
发表时间: 2008
期刊: Annals of Clinical Biochemistry (In press)
影响因子: --
作者: [Urata, M., et. al.]
通讯作者: et. al.
DOI: 10.1038/onc.2009.322
发表时间: 2010-01-14
期刊: ONCOGENE
影响因子: 8
作者: [Shiota, M., Yokomizo, A., Naito, S.]
通讯作者: Naito, S.
DOI: 10.1210/me.2009-0302
发表时间: 2010
期刊: Molecular endocrinology
影响因子: --
作者: [M. Shiota;A. Yokomizo;Y. Tada;J. Inokuchi;K. Tatsugami;K. Kuroiwa;T. Uchiumi;N. Fujimoto;N. Seki;S. Naito]
通讯作者: M. Shiota;A. Yokomizo;Y. Tada;J. Inokuchi;K. Tatsugami;K. Kuroiwa;T. Uchiumi;N. Fujimoto;N. Seki;S. Naito
31
    Analysis of mitochondrial functions in diseases
    • 批准号:
      22249018
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $31.03万
    • 财政年份:
      2010
    • 负责人:
      KANG Dongchon
    • 依托单位:
    Mitochondrial DNA analysis for diabetes cohort study
    • 批准号:
      21659148
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.24万
    • 财政年份:
      2009
    • 负责人:
      KANG Dongchon
    • 依托单位:
    Effect of mitochondrial transcription factor A (TFAM) on aging of mouse
    • 批准号:
      17390095
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.41万
    • 财政年份:
      2005
    • 负责人:
      KANG Dongchon
    • 依托单位:
    Identification of human mitochondrial metabolome proteins
    • 批准号:
      15390106
    • 项目类别:
      Grant-in-Aid for Scientific Research (B)
    • 资助金额:
      $9.86万
    • 财政年份:
      2003
    • 负责人:
      KANG Dongchon
    • 依托单位:
    海外基金