Development of novel gastrointestinal cancer diagnostic system based on large epige-nome analysis.

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Through analyzing epigenome and transcriptome in colorectal cancer (CRC) cells, we identified a number of microRNA genes which were epigenetically silenced in CRC. By analyzing colorectal premalignant lesions and early CRC tissues, we identified novel DNA methylation alterations, which could be potential biomarkers for early detection of CRCs. Moreover, we discovered a novel relationship between tumor surface microstructure, pathological findings and molecular alterations in the colorectal premalignant lesion. We carried out epigenome analysis the background gastric mucosa of primary gastric cancer (GC), and identified novel DNA methylation changes which could be novel GC risk markers. Finally, by performing epigenome analysis in primary hepatocellular carcinoma (HCC), we discovered novel DNA methylation changes, which could be novel HCC markers.