Molecular mechanisms of epigenetic alterations in gastrointestinal cancer and application to diagnosis and therapy

胃肠癌表观遗传改变的分子机制及其在诊断和治疗中的应用

• 批准号: 17109008
• 负责人: IMAI Kohzoh
• 金额: $ 70.89万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (S)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-17109008/
• 关键词: DNAメチル化; エピジェネティクス; ヒストン修飾; 個別化医療; 遺伝子診断; 分子標的治療; メチル化; 消化器癌; 遺伝子発現; 腫瘍マーカー; 分子標的

Molecular mechanisms how this epigenetic alterations contribute to development of tumors remains to be determined. DNA methylation also leads to silencing of genes involved in cell signaling, which in turn leads to dysregulation of the oncogenic signaling such as Ras, WNT, and microRNA. We found that epigenetic inactivation of IGFBP7 plays a critical role in escaping senescence in CIMP positive colorectal cancers. We also found that epigenetic information can be used to detect cancer cells from colorectal mucosal solution.

这种表观遗传改变如何促进肿瘤发展的分子机制仍有待确定。DNA甲基化还导致参与细胞信号传导的基因沉默，这反过来又导致致癌信号传导如Ras、WNT和microRNA的失调。我们发现IGFBP7的表观遗传失活在CIMP阳性结直肠癌中逃避衰老中起着关键作用。我们还发现，表观遗传信息可用于从结直肠粘膜溶液中检测癌细胞。

项目成果

Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis

• DOI: 10.1093/carcin/bgi029
• 发表时间: 2005-05-01
• 期刊: CARCINOGENESIS
• 影响因子: 4.7
• 作者: Nosho, K;Yoshida, M;Imai, K
• 通讯作者: Imai, K

IGF-I receptor is a candidate molecurar target for both human esophageal squamous cell carcinoma and adenocarcinoma.

IGF-I 受体是人食管鳞状细胞癌和腺癌的候选分子靶点。

• 发表时间: 2007
• 作者: Adachi Y;et. al.
• 通讯作者: et. al.

消化管病理標本の読み方改訂2版.

如何阅读胃肠道病理标本，修订第2版。

• 发表时间: 2008
• 作者: 豊田 実;他
• 通讯作者: 他

Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability

• DOI: 10.1016/j.canlet.2007.02.004
• 发表时间: 2007-08-28
• 期刊: CANCER LETTERS
• 影响因子: 9.7
• 作者: Miyamoto, Nobuki;Yamamoto, Hiroyuki;Shinomura, Yasuhisa
• 通讯作者: Shinomura, Yasuhisa

Recent Advances in Gastrointestinal Carcinogenesis

胃肠癌发生的最新进展

• 发表时间: 2006
• 作者: Higashi;H.
• 通讯作者: H.