Immunotherapy using humanized monoclonal antibody

使用人源化单克隆抗体的免疫疗法

• 批准号: 17016060
• 负责人: IMAI Kohzoh
• 金额: $ 88.7万
• 依托单位: Sapporo Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research on Priority Areas
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2009
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17016060/
• 关键词: ヒト抗体; 免疫療法; モノクローナル抗体; ヒト型抗体; 免疫治療; モロクローナル抗体

We have been developed the new monoclonal antibody against FGFR-1, which express on human hepatocellular carcinoma and induced by IFN. When we administrate this antibody and IFN simultaneously, strong anti-cancer effect was observed in vitro and in vivo. Furthermore, we have been developed other monoclonal antibodies aimed at therapy for gastric cancer. These are the humanized bispecific monoclonal antibody targeted tumor antigen×CD3 and the humanized trifunctional bispecific antibody which have the Fc region.

我们开发了针对 FGFR-1 的新型单克隆抗体，FGFR-1 在人肝细胞癌上表达并由 IFN 诱导。当我们同时给予该抗体和IFN时，在体外和体内均观察到很强的抗癌作用。此外，我们还开发了其他旨在治疗胃癌的单克隆抗体。它们是靶向肿瘤抗原×CD3的人源化双特异性单克隆抗体和具有Fc区的人源化三功能双特异性抗体。

项目成果

Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis

• DOI: 10.1093/carcin/bgi029
• 发表时间: 2005-05-01
• 期刊: CARCINOGENESIS
• 影响因子: 4.7
• 作者: Nosho, K;Yoshida, M;Imai, K
• 通讯作者: Imai, K

Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability

• DOI: 10.1016/j.canlet.2007.02.004
• 发表时间: 2007-08-28
• 期刊: CANCER LETTERS
• 影响因子: 9.7
• 作者: Miyamoto, Nobuki;Yamamoto, Hiroyuki;Shinomura, Yasuhisa
• 通讯作者: Shinomura, Yasuhisa

Activation of the ribosomal protein L13 gene in human gastrointestinal cancer.

• DOI: 10.3892/ijmm.18.1.161
• 发表时间: 2006-07
• 期刊: International journal of molecular medicine
• 影响因子: 5.4
• 作者: Toshihisa Kobayashi;Y. Sasaki;Yuichiro Oshima;Hiroyuki Yamamoto;H. Mita;Hiromu Suzuki;M. Toyota

Anti-tumor Efficacy of anti-FGFR1 monoclonal antibody for human hepatoma Cells.

抗FGFR1单克隆抗体对人肝癌细胞的抗肿瘤功效。

• 发表时间: 2008
• 作者: Muroyama R;Kato N;Otsuka M;Chang JH;Omata M.;Muroyama R;Sasaki S
• 通讯作者: Sasaki S

FGFR1抗体と二重特異性抗体

FGFR1 抗体和双特异性抗体

• 发表时间: 2008
• 作者: 坂本穣;前川伸哉;榎本信幸;室山良介;坂本穣;雨宮史武;安井寛
• 通讯作者: 安井寛