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Immunotherapy using humanized monoclonal antibody

Immunotherapy using humanized monoclonal antibody
使用人源化单克隆抗体的免疫疗法
批准号:
17016060
负责人:
IMAI Kohzoh
金额:
$88.7万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research on Priority Areas
财政年份:
2005
资助国家:
日本
项目状态:
已结题
起止时间:
2005 至 2009

项目摘要

项目成果

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中文摘要
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英文摘要
We have been developed the new monoclonal antibody against FGFR-1, which express on human hepatocellular carcinoma and induced by IFN. When we administrate this antibody and IFN simultaneously, strong anti-cancer effect was observed in vitro and in vivo. Furthermore, we have been developed other monoclonal antibodies aimed at therapy for gastric cancer. These are the humanized bispecific monoclonal antibody targeted tumor antigen×CD3 and the humanized trifunctional bispecific antibody which have the Fc region.
期刊论文(93)
专著(0)
科研奖励(0)
会议论文
DOI: 10.1093/carcin/bgi029
发表时间: 2005-05-01
期刊: CARCINOGENESIS
影响因子: 4.7
作者: [Nosho, K, Yoshida, M, Imai, K]
通讯作者: Imai, K
DOI: 10.1016/j.canlet.2007.02.004
发表时间: 2007-08-28
期刊: CANCER LETTERS
影响因子: 9.7
作者: [Miyamoto, Nobuki, Yamamoto, Hiroyuki, Shinomura, Yasuhisa]
通讯作者: Shinomura, Yasuhisa
DOI: 10.3892/ijmm.18.1.161
发表时间: 2006-07
期刊: International journal of molecular medicine
影响因子: 5.4
作者: [Toshihisa Kobayashi;Y. Sasaki;Yuichiro Oshima;Hiroyuki Yamamoto;H. Mita;Hiromu Suzuki;M. Toyota]
通讯作者: Toshihisa Kobayashi;Y. Sasaki;Yuichiro Oshima;Hiroyuki Yamamoto;H. Mita;Hiromu Suzuki;M. Toyota
Anti-tumor Efficacy of anti-FGFR1 monoclonal antibody for human hepatoma Cells.
抗FGFR1单克隆抗体对人肝癌细胞的抗肿瘤功效。
DOI: --
发表时间: 2008
期刊:
影响因子: --
作者: [Muroyama R, Kato N, Otsuka M, Chang JH, Omata M., Muroyama R, Sasaki S]
通讯作者: Sasaki S
74
    Identification of specific cancer stem cell markers for diagnosis
    • 批准号:
      24650632
    • 项目类别:
      Grant-in-Aid for Challenging Exploratory Research
    • 资助金额:
      $2.5万
    • 财政年份:
      2012
    • 负责人:
      IMAI Kohzoh
    • 依托单位:
    Development of novel gastrointestinal cancer diagnostic system based on large epige-nome analysis.
    • 批准号:
      23240129
    • 项目类别:
      Grant-in-Aid for Scientific Research (A)
    • 资助金额:
      $31.62万
    • 财政年份:
      2011
    • 负责人:
      IMAI Kohzoh
    • 依托单位:
    Scientific Support Programs for Cancer Research Grant-in-Aid for Scientific Research on Innovative Areas
    • 批准号:
      221S0001
    • 项目类别:
      Grant-in-Aid for Scientific Research on Innovative Areas (Research in a proposed research area)
    • 资助金额:
      $0.0万
    • 财政年份:
      2010
    • 负责人:
      IMAI Kohzoh
    • 依托单位:
    Molecular mechanisms of epigenetic alterations in gastrointestinal cancer and application to diagnosis and therapy
    • 批准号:
      17109008
    • 项目类别:
      Grant-in-Aid for Scientific Research (S)
    • 资助金额:
      $70.89万
    • 财政年份:
      2005
    • 负责人:
      IMAI Kohzoh
    • 依托单位:
    海外基金