Regulation of bone resorption in jaw by the drug administration. Analysis by the 3D-bone histomorphometry and by the measurement of bone mineral density.

为了开发抑制和调节颌骨骨吸收的药物治疗方法，进行了以下研究。1)骨吸收动物模型实验采用低钙和高盐两种喂养方式，通过三维骨组织形态测量和骨密度测量分析大鼠下颌骨的变化。双膦酸盐抑制了低钙喂养引起的骨吸收，显著提高了骨密度。高盐摄入刺激下颌骨骨吸收，这是由于高血压影响下骨重塑的解耦。2)牵张成骨兔实验。兔牵张成骨后再生骨在术后短时间内增加了骨密度和机械强度。因此，建议在骨密度和机械强度较高的时期取出固定装置，这一时期可能比目前临床治疗所用的时间短。

The following research was performed in order to develop the drug treatment for inhibiting and regulating bone resorption in jaw.1) Experiments using the animal model for bone resorptionRats were fed either a low calcium diet or a high salt diet and then changes of mandibular bone were analyzed by the 3D-bone histomorphometry as well as by the measurement of bone mineral density. Bisphosphonates prevented the bone resorption induced by the low calcium feeding and the increase of mineral density was remarkable. High salt intake stimulated bone resorption in mandibule and this was due to the uncoupling of bone remodeling under the influence of high blood pressure.2) Experiments using the rabbit after the distraction osteogenesis.Regenerated bone after the distraction osteogenesis in rabbit increased bone mineral density as well as mechanical strength within a short period after surgery. It is suggested, therefore, the possibility to remove the fixation device at the period showing high bone mineral density and mechanical strength and this period might be shorter than that have been used in the present clinical therapy.