Development of TNF-receptor Antagonists which have both Anti-inflammatory Action and Bone Formation Activity and Apply Them for the Treatment of Periodontal Diseases.
Development of TNF-receptor Antagonists which have both Anti-inflammatory Action and Bone Formation Activity and Apply Them for the Treatment of Periodontal Diseases.
批准号:
24390413
负责人:
OHYA Keiichi
金额:
$11.73万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2015-03-31
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硬組織薬理学分野
硬组织药理学
DOI:
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发表时间:
期刊:
影响因子:
--
作者:
[]
通讯作者:
Stimulation of bone formation in cortical bone of mice treated with a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that possesses osteoclastogenesis inhibitory activity.
用核因子 - κB配体(RANKL)结合肽的受体激活剂治疗的小鼠的皮质骨刺激骨形成,该肽具有破骨构成抑制活性。
DOI:
10.1074/jbc.m112.426080
发表时间:
2013-02-22
期刊:
The Journal of biological chemistry
影响因子:
--
作者:
[Furuya Y, Inagaki A, Khan M, Mori K, Penninger JM, Nakamura M, Udagawa N, Aoki K, Ohya K, Uchida K, Yasuda H]
通讯作者:
Yasuda H
An Osteoprotegerin-like Peptide Inhibits Bone Loss in Collagen Type II-Induced Murine Arthritis.
骨保护素样肽可抑制 II 型胶原蛋白诱导的小鼠关节炎中的骨质流失。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Kato, G. Maeda, M. Alles, N. Mamun, A. Khan, M. Sugamori, Y. Takahashi, M. Tamura, Y. Murali, R. Ohya, K. Aoki, K.]
通讯作者:
K.
Ⅱ型ウシコラーゲン誘導のマウス関節リウマチモデルを用いたRANKL結合ペプチドの骨形成促進作用と骨吸収抑制作用.
使用 II 型牛胶原诱导的小鼠类风湿性关节炎模型,研究 RANKL 结合肽的骨形成促进和骨吸收抑制作用。
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[加藤玄樹, 清水康広, 菅森泰隆, 田村幸彦, 小野卓史, 大谷啓一, 青木和広.]
通讯作者:
青木和広.
DOI:
10.11480/jmds.590301
发表时间:
2012-11
期刊:
Journal of medical and dental sciences
影响因子:
--
作者:
[N. Soysa;N. Alles;K. Aoki;K. Ohya]
通讯作者:
N. Soysa;N. Alles;K. Aoki;K. Ohya
共 17 条
New bone resrption inhibitor based on agonistic function for TNF type 2 receptor
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批准号:25670787
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.41万
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财政年份:2013
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负责人:OHYA Keiichi
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依托单位:
Development of new therapeutic drugs for inflammatory bone destruction by the CIAM compound, a new TNF receptor antagonist.
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批准号:19390471
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.48万
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财政年份:2007
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负责人:OHYA Keiichi
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依托单位:
Development of New Hybrid-type Drugs Targeted to the Mechanism of Bone Remodeling
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批准号:16209053
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项目类别:Grant-in-Aid for Scientific Research (A)
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资助金额:$31.12万
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财政年份:2004
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负责人:OHYA Keiichi
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依托单位:
Search for the new target points of bisphosphonates in bone cells: Their inhibitory actions on bone resorption and the stimulatory actions on bone formation
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批准号:13470391
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.77万
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财政年份:2001
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负责人:OHYA Keiichi
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依托单位:
Regulation of bone resorption in jaw by the drug administration. Analysis by the 3D-bone histomorphometry and by the measurement of bone mineral density.
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批准号:11557134
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$8.32万
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财政年份:1999
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负责人:OHYA Keiichi
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依托单位:
DEVELOPMENT OF DRUG WHICH REGULATES BONE RESORPTION ACTIVITY IN OSTEOCLASTS VIA CYTOSKELTON AND SIGNAL TRANSDUCTION SYSTEM
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批准号:09470400
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$6.08万
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财政年份:1997
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负责人:OHYA Keiichi
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依托单位:
DRUG REGULATIONS OF BONE RESORPTION IN ALVEOLAR BONE AND ITS MECHANISM OF ACTION
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批准号:05454499
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.97万
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财政年份:1993
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负责人:OHYA Keiichi
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依托单位:
A STUDY OF THE NEW INHIBITORY DRUG FOR BONE RESORPTION, BISPHOSPHONATES, ON THE ALVEOLAR BONE RESORPTION PROCESS.
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批准号:03670863
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项目类别:Grant-in-Aid for General Scientific Research (C)
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资助金额:$1.34万
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财政年份:1991
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负责人:OHYA Keiichi
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依托单位:
海外基金