Understanding and monitoring renal microvascular remodeling in CKD by super-resolution ultrasound.
通过超分辨率超声了解和监测 CKD 肾微血管重塑。
基本信息
- 批准号:459589123
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:德国
- 项目类别:Clinical Research Units
- 财政年份:
- 资助国家:德国
- 起止时间:
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Pathological microvascular remodeling and microvascular dysfunction are common findings and contributing factors in progressive chronic kidney diseases (CKD), but in-vivo imaging methods that allow for their quantification are not available. Recently, we developed a super-resolution ultrasound method, enabling a highly detailed microvascular characterization of tissues at the morphologic and functional level. The method relies on the injection of clinically used gas-filled microbubbles as contrast agents and their tracking with algorithms known from GPS and radar. The resulting tracks are displayed at a resolution corresponding to the localization accuracy, which goes far beyond the resolution limits of the ultrasound devices. In addition, the method allows for quantification of blood velocity and direction within single capillaries, i.e. functional analyses of microvascular dynamics. We here aim to develop super-resolution ultrasound for experimental and clinical nephrology to analyze microvascular alterations in kidney diseases. Our preliminary data show that kidney vasculature can be visualized at super-resolution in mice and humans, but significant modifications of the scanning protocol, data processing and image analysis will be required to achieve the same quality as in tumors or the brain. Our aims are to (i) modify the protocol to analyze the renal microvasculature in mice and humans and to (ii) investigate renal microvascular remodeling during the transition from acute kidney injury (AKI) to CKD. As a proof-of-concept study we will analyze the role of macrophage migration inhibitory factor (MIF) on microvascular remodeling. To achieve this task, our team combines experts in imaging (Kiessling), data analysis (Schmitz) and translational nephrology (Djudjaj). Super-resolution ultrasound is a non-invasive method and we already used it in a clinical trial on breast cancer patients. In cooperation with clinical nephrologists within the consortium we also aim to (iii) perform a first clinical trial with patients with different stages of CKD. Finally, we will (iv) perform radiomic analyses to evaluate the additional benefit of parameters extracted from super-resolution ultrasound data.
病理性微血管重塑和微血管功能障碍是进行性慢性肾脏疾病(CKD)的常见发现和促成因素,但目前尚无法使用体内成像方法对其进行定量。最近,我们开发了一种超分辨率超声方法,能够在形态和功能水平上对组织进行非常详细的微血管表征。该方法依赖于注射临床使用的充气微泡作为造影剂,并使用GPS和雷达已知的算法对其进行跟踪。所得到的轨迹以与定位精度相对应的分辨率显示,这远远超出了超声设备的分辨率限制。此外,该方法允许量化单个毛细血管内的血液速度和方向,即微血管动力学的功能分析。我们的目标是开发超分辨率超声用于实验和临床肾脏学,以分析肾脏疾病中的微血管改变。我们的初步数据表明,肾脏血管可以在小鼠和人类中以超分辨率可视化,但需要对扫描协议,数据处理和图像分析进行重大修改,以达到与肿瘤或大脑相同的质量。我们的目的是(i)修改方案以分析小鼠和人类的肾脏微血管,(ii)研究从急性肾损伤(阿基)向CKD过渡期间的肾脏微血管重塑。作为概念验证研究,我们将分析巨噬细胞移动抑制因子(MIF)对微血管重塑的作用。为了完成这项任务,我们的团队结合了成像(Kiessling),数据分析(Schmitz)和翻译肾脏学(Djudjaj)的专家。超分辨率超声是一种非侵入性方法,我们已经将其用于乳腺癌患者的临床试验。与联盟内的临床肾病学家合作,我们还旨在(iii)对不同阶段的CKD患者进行首次临床试验。最后,我们将(iv)进行放射组学分析,以评估从超分辨率超声数据中提取的参数的额外益处。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Professor Dr. Fabian Kiessling其他文献
Professor Dr. Fabian Kiessling的其他文献
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{{ truncateString('Professor Dr. Fabian Kiessling', 18)}}的其他基金
Development of Motion-Model Ultrasound Localization Microscopy to Support Breast Cancer Diagnosis and Therapy Monitoring in Patients
开发运动模型超声定位显微镜以支持乳腺癌诊断和患者治疗监测
- 批准号:
233312120 - 财政年份:2013
- 资助金额:
-- - 项目类别:
Research Grants
Personalizing EPR-mediated passive drug targeting to tumors using non-invasive imaging
使用非侵入性成像个性化 EPR 介导的被动药物靶向肿瘤
- 批准号:
194806083 - 财政年份:2011
- 资助金额:
-- - 项目类别:
Research Grants
Entwicklung und Erprobung multimodaler molekularer Proben für die in vivo Charakterisierung der Stabilität atherosklerotischer Plaques
用于动脉粥样硬化斑块稳定性体内表征的多模式分子样品的开发和测试
- 批准号:
170386255 - 财政年份:2010
- 资助金额:
-- - 项目类别:
Research Units
Optimierung von E-Selektin spezifischen Ultraschallkontrastmitteln und deren Nachweis in experimentellen Mammakarzinomen mit quantitativen Ultraschalltechniken
E-选择素特异性超声造影剂的优化及其在实验性乳腺癌中使用定量超声技术的检测
- 批准号:
157638599 - 财政年份:2010
- 资助金额:
-- - 项目类别:
Research Grants
Ausrichtung der Exzellenzakademie Medizintechnik über Molekulare Bildgebung
卓越医学技术学院分子影像方向
- 批准号:
163729647 - 财政年份:2009
- 资助金额:
-- - 项目类别:
Research Grants
Vergleich von fluoreszenzbasierter Bildgebung und Volumen-CT und MRT für das Staging und Therapiemonitoring experimenteller Kolonkarzinome und Multipler Myelome
荧光成像与体积 CT 和 MRI 对实验性结肠癌和多发性骨髓瘤分期和治疗监测的比较
- 批准号:
47141331 - 财政年份:2007
- 资助金额:
-- - 项目类别:
Research Grants
Development of Fluorescent and Magnetic Dual-Functional Probes for Molecular Imaging of Prostate Cancers
开发用于前列腺癌分子成像的荧光和磁性双功能探针
- 批准号:
5436487 - 财政年份:2004
- 资助金额:
-- - 项目类别:
Research Grants
Imaging in the context of 3R: chances and threats
3R 背景下的成像:机遇与威胁
- 批准号:
329693114 - 财政年份:
- 资助金额:
-- - 项目类别:
Research Units
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