NSF-DFG Echem: Electrochemical Hydrogenation of Amides and Esters

NSF-DFG Echem：酰胺和酯的电化学氢化

• 批准号: 459920716
• 负责人: Professorin Dr. Inke Siewert
• 金额: --
• 依托单位: Institut für Anorganische Chemie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/459920716?language=en
• 关键词: NSF; DFG; Echem; Electrochemical; Hydrogenation

The hydrogenation of carboxylic acid derivatives such as esters and amides represents an atom economic process for the production of synthetically valuable alcohols and amines. As a primary biological functional group, amides are ubiquitous both in natural chemical compounds and in therapeutic agents. Hydrogenation via the cleavage of C-O or C-N bonds offers a direct route to valuable amines and alcohols (or water). Esters are also frequently encountered, and hydrogenation offers a highly attractive synthetic route to the corresponding alcohols. Traditionally, the reduction of esters and amides is achieved through the use using stoichiometric reducing agents such as LiAlH4 or samarium iodide. However, this leads to a significant amount of waste and the reactions are often not functional group tolerant. Therefore, it has long been a challenge to find efficient and selective catalytic methods for the reduction of esters to alcohols and amides to amines and alcohols as alternatives.Recently, electrochemistry has been used more frequently for the construction of (organic) molecules, as it allows to use energy directly from renewable sources. Thus, it represents a versatile tool for energy- and atom economic synthes. The research project aims at the catalytic hydrogenation of esters and amides with electrons and protons. Base metal complexes are used as catalysts. is.

羧酸衍生物如酯和酰胺的氢化反应是一种原子经济的过程，用于生产有合成价值的醇和胺。酰胺作为一种主要的生物功能基团，在天然化合物和治疗剂中都广泛存在。通过C-O或C-N键的裂解进行的氢化反应为生成有价值的胺和醇（或水）提供了一条直接途径。酯也经常遇到，氢化提供了一个非常有吸引力的合成途径，以相应的醇。传统上，酯和酰胺的还原是通过使用化学计量还原剂，如LiAlH4或碘化钐来实现的。然而，这会导致大量的浪费，而且反应通常不能耐受官能团。因此，寻找高效和选择性的催化方法将酯还原为醇和酰胺还原为胺和醇作为替代品一直是一个挑战。最近，电化学更频繁地用于（有机）分子的构建，因为它允许直接使用来自可再生能源的能量。因此，它代表了能源和原子经济合成的多功能工具。该研究项目旨在用电子和质子催化酯和酰胺的氢化反应。贱金属配合物用作催化剂。是多少。