Mechanism of metabolism and function of rubidium in body

铷在体内的代谢机制和作用

• 批准号: 12470088
• 负责人: CHIBA Momoko
• 金额: $ 2.37万
• 依托单位: JUNTENDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12470088/
• 关键词: Rubidium(Rb); ATPase; Serum; Cerebrospinal Fluid (CSF); Human; Rat; Mouse; Senescence Accelerated Mouse(SAM); カリウム; ヒト脳内ルビジウム; ラット脳内ルビジウム; 老化促進マウス脳内ルビジウム; Na・K-ATPase活性; 必須元素; 微量元素; 正常値; 低ルビジウム食; ホメオスタシス

1. Rb concentrations (concn) in serum of healthy adults were 0.41±0.18μg/ml (mean ±SD) in males and 0.33±0.15μg/ml in females. Rb concn in human brain without diseases were the same levels in 5 regions ; about 10μg/g of Rb. Significant negative correlation between Rb concn and age was found in each region. Serum and CSF of patients of neurology departments were analysed. Rb concn in CSF were 1/4 of those in serum, and no correlation with diseases 2. Rb concn in 8 regions of rat brains and correlation with age were similar to human brain. 3. Rb concentration in 8 regions of brains of SAMRl and SAMP10 were no difference among regions like rats. Rb concn in 7 regions of P10 were significantly higher than R1 at 3 months old. There was no correlation with age. 4.In mice after feeding with low Rb diet, Rb concn in bone was 1/5, and in spleen was 1/2 of the controls, but no change in brain, liver, kidney, lung, pancreas, and thymus. 5.In mice fed with four kinds of diets, which were different contents of Rb and K, ATPase activity in blood, liver and kidney were assayed. Total ATPase、 Ca-ATPase、 Mg-ATPase and Na・K-ATPase activities were observed. Total ATPase activities were kidney>liver >blood. Activities in blood showed correlation with the sort of diet.

1.健康成人血清Rb浓度为0.41±0.18μg/ml（均数±标准差），女性为0.33±0.15μg/ml。正常人脑内5个脑区Rb含量均在10μg/g左右。各部位Rb含量与年龄呈显著负相关。对神经内科住院患者的血清和脑脊液进行分析。脑脊液中Rb含量为血清的1/4，与疾病无关。大鼠脑内8个脑区Rb含量及其与年龄的相关性与人脑相似。3. SAMR 1和SAMP 10的8个脑区Rb含量与大鼠相似，无明显差异。3月龄时P10的7个区域Rb含量均显著高于R1。与年龄无关。4.低Rb组小鼠骨中Rb含量为对照组的1/5，脾中Rb含量为对照组的1/2，脑、肝、肾、肺、胰、胸腺中Rb含量无明显变化。5.测定了四种不同Rb、K含量的饲料对小鼠血液、肝脏和肾脏ATP酶活性的影响。测定了总ATP酶、Ca-ATP酶、Mg-ATP酶和Na·K-ATP酶的活性。总ATP酶活性为肾>肝>血。血液中的活性与饮食类型相关。