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Effects of thallium on biological bodies

铊对生物体的影响

基本信息

批准号：
04670315
负责人：
CHIBA Momoko
金额：
$ 1.34万
依托单位：
Juntendo University School of Medicine
依托单位国家：
日本
项目类别：
Grant-in-Aid for General Scientific Research (C)
财政年份：
1992
资助国家：
日本
起止时间：
1992 至 1993
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04670315/
关键词：
Thallium Mouse Oral Dministration Distribution Excretion Biological monitoring

项目摘要

PURPOSE Thallium (Tl) is highly toxic, therefore, they quitted using it as the medical treatments, in secticides or redenticides. REcently, Tl is given attention as a material for semiconductors or advanced composites. Our main purpose of this study is to know the fate of Tl in animal bodies.METHODS Male mice at 6 week old started drinking water containig 0.2 to 20 ppm Tl for 1 or 3 weeks. The other mice received single administration of 50 mumol Tl/kg directly to stomach. The other mice were given Tl by combination of drinking water and oral injection. One, 3, 7, 22, or 43 days after cessation of Tl intake, mice were sacrificed and almost all organs, blood, contents in gastro-intestinal tract, urine, and feces, 20 items per mouse were kept for Tl determination.RESULTS AND DISCUSSION 1. Every kind of analytical specimen contained Tl. 2. Disappearance of Tl from each organ was relatively rapid after cessation of Tl intake. Wehn low dose was supplied, Tl concentrations in organs were 1/2 after 3 days, and 1/10 after 1 week. 3. Tl excretion into urine was 10 - 30%, and 35-60% or total amount ingested. 4. The highest Tl concentration was found in bone and showed the slowest attenuation. 5. Tests, submandibular gland, and gastrointestinal tracts showed high affinity to Tl. 6. Tl concentration in hair had positive correlation with Tl dose administered. 7. The activities of serum GOT, Al-P, and blood ALAD were not affected by Tl.CONCLUSION Tl invading into body orally distributes almost all organs. Disappearance of Tl from organs was relatively fast. Body hair is useful for biological monitoring.

铊（Tl）具有很强的毒性，因此，人们放弃了将其作为药物治疗、杀虫剂或杀鼠剂的使用。最近，Tl作为用于半导体或高级复合材料的材料受到关注。方法雄性小鼠6周龄开始饮用含0.2 ~ 20 ppm铊的水1 ~ 3周。其他小鼠接受50 mumol Tl/kg直接胃单次给药。其他小鼠通过饮用水和口服注射的组合给予T1。在停止摄入铊后1、3、7、22或43天，处死小鼠，保留几乎所有的器官、血液、胃肠道内容物、尿液和粪便，每只小鼠20个项目用于铊测定。各种分析样品均含有铊。2.停止摄入铊后，各器官中铊的消失相对较快。当提供低剂量时，3天后器官中的铊浓度为1/2，1周后为1/10。3.排泄到尿中的Tl为10 - 30%，并且为摄入总量的35-60%。4.在骨中发现最高的Tl浓度并且显示最慢的衰减。5.试验、下颌下腺和胃肠道显示对Tl的高亲和力。6.发中铊浓度与给药剂量呈正相关。7.铊对血清GOT、Al-P、ALAD活性无明显影响。结论铊经口侵入人体后，几乎分布于所有器官。Tl从器官中消失相对较快。体毛对生物监测很有用。