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Health problem due to magnesium and/or potassium deficiency-Experimental study using stable isotope-

镁和/或钾缺乏引起的健康问题-使用稳定同位素的实验研究-

基本信息

批准号：
09470104
负责人：
CHIBA Momoko
金额：
$ 7.87万
依托单位：
Juntendo University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1998
项目状态：
已结题

项目摘要

Sudden death cases, which were considered due to over work or stress, were happened in Asian countries including Japan. Many cases were young males. We have estimated that the hypothesis would be chronic disorder of mineral balance as well as stress. Deficiency of magnesium (Mg) and potassium (K) was paid attention.1. Mortality rates were observed in male and female mice given Mg and/or K deficient diet. (1) no sexual difference was observed in mice given only Mg deficient diet, (2) in young mice given Mg/K deficient diet, males were died within 2 weeks, while all females were survived, and in 4 month old mice, the mortality curves were shifted 1 week later, (3) in mice received castration and given Mg/K deficient diet, no sexual difference was observed in mortality rate.2. As the natural results, Mg concentrations were extremely low in various organs of mice fed Mg deficient diet, however, Mg concentration in heart and kidney were kept at the normal ranges.3. After intravenous injection with stable isotope 26Mg, considerable amount of 26Mg was found in heart and kidney. In heart 26Mg was increasing up to 6 hours.4. Lipid peroxide and mineral balance were observed in mice housing in the normal conditions (23 C, 60%) or in hot conditions (30 C, 60%) and given normal or Mg/K deficient diet. Lipid peroxide increased in mice housing in hot conditions, and independent from diet. Disorder of mineral balance was appeared in male mice fed Mg/K deficient diet and housing in hot conditions.As conclusion, young male mice were susceptible for Mg and/or K deficiency, and their homeostasis was injured.

被认为是工作过度或压力过大的猝死案例发生在包括日本在内的亚洲国家。许多病例是年轻男性。我们估计，假说将是慢性矿物质平衡紊乱和压力。镁(Mg)和钾(K)缺乏引起了人们的关注。观察了给予镁和/或钾缺乏饮食的雄性和雌性小鼠的死亡率。(1)单纯饲喂低镁饲料的小鼠无性别差异；(2)饲喂低镁低钾饲料的幼鼠，雄性在2周内死亡，雌性全部存活，4月龄小鼠的死亡曲线在1周后移动；(3)去势和低镁低钾饲料的小鼠死亡率没有性别差异。作为自然结果，饲喂低镁饲料的小鼠各器官中镁浓度极低，而心脏和肾脏中镁浓度维持在正常范围内。静脉注射稳定同位素26 mg后，在心脏和肾脏中发现相当数量的26 mg。在心脏中，26 mg的剂量增加到6小时。在正常条件下(23℃，60%)和高温条件下(30℃，60%)以及给予正常或镁/钾缺乏饮食的小鼠中，观察到脂质过氧化和矿物质平衡。在高温条件下，小鼠体内的过氧化脂质增加，且与饮食无关。在高温条件下饲喂低镁低钾饲料的雄性小鼠出现矿物质平衡紊乱。结论：幼年雄性小鼠易患镁和/或钾缺乏，体内平衡受损。