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Study for Pathophysiology in Vitreo-retinal surgery

玻璃体视网膜手术的病理生理学研究

基本信息

批准号：
12470361
负责人：
TERASAKI Hiroko
金额：
$ 7.81万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2000
资助国家：
日本
起止时间：
2000 至 2001
项目状态：
已结题

项目摘要

We studied the effects of vitreoretinal surgery on retinal function and morphology. Vitrectomy is one of the effective treatments for improvements of retinal pathological conditions by removing the diseased vitreous and proliferative tissues. Conversely, however, the procedure itself may give adverse effects on the retinal function and/or retinal circulation. We evaluated the effects of removal of internal limiting membrane on macular retinal function in idiopathic macular hole surgery by focal macular ERG (FMERG) and concluded that this procedure had no adverse effect on visual acuity. However, the selective delay of recovery of the FMERG b-wave after surgery suggests an alteration of retinal physiology in the macular region(IOVS200 1). We further evaluated the macular morphology using optical coherent tomography in diabetic macular edema with visible vitreous traction and concluded that the structure recovered well after surgery, although the recovery of visual acuity was limited because of their preoperative retinal pahological conditions(AJO2001). We further studied the local macular and full-field retinal functions of age related macular degeneration (AMD) after removal of choroidal neovascularization and macular translocation surgery, respectively(IOVS2002) (IOVS2002). These study demonstrated the recovery of macular function was contributed by the decreased retinal thickness. Macular translocation surgery may be well feasible technique, however, the total function of the retina was decreased after surgery. In our additional study, the histopathology of polypoidal choroidal vasculopathy obtained during macular translocation surgery demonstrated the similarity to those of the AMD(BJO2002).

我们研究了玻璃体视网膜手术对视网膜功能和形态的影响。玻璃体切除术是通过切除病变玻璃体和增生组织来改善视网膜病变的有效治疗方法之一。然而，相反，手术本身可能对视网膜功能和/或视网膜循环产生不利影响。我们通过焦点黄斑ERG（FMERG）评价了特发性黄斑裂孔手术中内界膜去除对黄斑视网膜功能的影响，并得出结论，该手术对视力无不良影响。然而，术后FMERG b波恢复的选择性延迟表明黄斑区视网膜生理学的改变（IOVS 200 1）。我们使用光学相干断层扫描进一步评价了糖尿病性黄斑水肿伴可见玻璃体牵引的黄斑形态，并得出结论，该结构在手术后恢复良好，尽管由于术前视网膜病理学状况，视力恢复有限（AJO 2001）。我们进一步研究了年龄相关性黄斑变性（AMD）在脉络膜新生血管切除术和黄斑移位手术后的局部黄斑和全视野视网膜功能（IOVS 2002）（IOVS 2002）。这些研究表明，黄斑功能的恢复与视网膜厚度的减少有关。黄斑移位术是一种可行的手术方法，但术后视网膜的整体功能下降。在我们的附加研究中，在黄斑移位手术期间获得的息肉状脉络膜血管病变的组织病理学证明了与AMD的相似性（BJO 2002）。