权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Study on endoscopic fluorescein angiography of extreme peripheral retina

内镜下视网膜末梢荧光血管造影研究

基本信息

批准号：
09671791
负责人：
TERASAKI Hiroko
金额：
$ 2.11万
依托单位：
Nagoya University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 1999
项目状态：
已结题

项目摘要

We developed intraoperative fluorescein angiography during vitrectomy using ophthalmic endoscope. We studied the fluorescein findings of extreme retinal periphery and ciliary body which had not been observed by regular fundus camera. First of all, we found that many eyes with proliferative diabetic retinopathy showed unusual findings in the extreme retinal periphery, which correlated the severity of retinal circulatory disturbances. Second, we applied this technique for the inflammatory disease such as bacterial endophthalmitis and uveitis. In bacterial endophthalmitis, the fluorescein findings appeared normal despite the severe functional abnormalities of the retina, which might be reversible retinal damage of inner retina by bacterial endotoxins. In uveitis, the fluorescein angiography revealed the neovascularization at the pars plana of ciliary body during surgery for vitreous hemorrhage which we could treat successfully at the time of surgery. We concluded that the neovascularization could develop during the inflammatory process not associated with vascular occlusion. Third, we successfully analyzed the mean retinal circulation time directly by recording the fluorescein angiography during operation.In addition to fluorescein angiography, we successfully recorded intraoperative indocyanin green angiography for patients with proliferative diabetic retinopathy and age-related macular degeneration in which we found choroidal new vessels remained frequently even after surgical removal. Age-related macular degeneration has become one of chief cause of blindness which we should continue to fight against with these new techniques.

我们在玻璃体切除术中使用眼科内窥镜进行术中荧光素血管造影。我们研究了常规眼底照相机无法观察到的视网膜边缘和睫状体的荧光素表现。首先，我们发现许多患有增生性糖尿病视网膜病变的眼睛在视网膜边缘显示出异常的发现，这与视网膜循环障碍的严重程度相关。其次，我们将这项技术应用于炎症性疾病，如细菌性眼内炎和葡萄膜炎。在细菌性眼内炎中，尽管视网膜功能严重异常，但荧光素检查结果仍正常，这可能是细菌内毒素对内层视网膜造成的可逆性视网膜损伤。在葡萄膜炎中，荧光素血管造影显示在玻璃体出血手术期间睫状体平坦部新生血管形成，我们可以在手术时成功治疗。我们的结论是，新血管形成可以在与血管闭塞无关的炎症过程中发展。第三，我们成功地通过记录术中荧光素血管造影直接分析了平均视网膜循环时间，除了荧光素血管造影外，我们还成功地记录了增殖性糖尿病视网膜病变和年龄相关性黄斑变性患者的术中吲哚菁绿色血管造影，我们发现即使在手术切除后，脉络膜新生血管仍然频繁存在。视网膜相关性黄斑变性已成为致盲的主要原因之一，我们应继续与这些新技术作斗争。