Elucidating the molecular pathology and development of treatment modalities for ischemic retinopathies

血管内皮生长因子的眼内动力学在包括视网膜分支静脉阻塞在内的缺血性视网膜病变的发病机制中起着关键作用。事实证明，长期抑制眼内血管内皮生长因子水平对维持视力很重要。在用小鼠进行的实验中，外周循环中的炎性细胞的作用被证明不是视网膜新生血管形成的关键。同时，玻璃体中的巨噬细胞在这方面可能是重要的。

The intraocular dynamics of VEGF plays a critical role in the pathogenesis of ischemic retinopathy including branch retinal vein occlusion. The long term suppression of intraocular VEGF levels proved important to maintain vision. In the experiments using mice, the role of inflammatory cells in the peripheral circulation was shown not to be essential for the formation of retinal neovascularization. Meanwhile, macrophages in the vitreous may be important in this aspect.