Development of Measurement and Analysis System for Heart Rate Variability

心率变异性（HRV）已被广泛用作人体自主神经活动的指标。最近，许多非侵入性的尝试，估计自主平衡已经进行了使用频谱分析的HRV。心率变异性（HRV）包括两个主要部分：呼吸性窦性心律失常（RSA）和Mayer波相关性窦性心律失常（MWSA）。RSA是伴随呼吸的心率变化，由副交感神经介导。MWSA与周期性血压变化（Mayer波）有关，并由交感神经和副交感神经介导。在许多关于心率变异性的研究中，MWSA和RSA的谱功率分别被称为LF（低频）和HF（高频）。LF/HF比值已被用作人体自主平衡的指标。然而，HRV测量的程序尚未得到验证。特别是呼吸作用的变化不仅对高频成分有影响，而且对低频成分也有影响。我们研制了三种心率变异性测量和分析的计算机软件（实时心率变异性监测系统、POLAR S-810分析系统和长期心率变异性监测系统），并特别考虑了呼吸对心率变异性的影响。本报告显示了系统的特性和技术细节以及测量的样本结果。

Heart rate variability (HRV) has been widely used as an index of human autonomic nervous activity. Recently, numerous noninvasive attempts to estimate the autonomic balance have been conducted using spectral analysis of HRV. HRV is composed of two major components: Respiratory sinus arrhythmia (RSA) and Mayer wave related sinus arrhythmia (MWSA). RSA is variation of heart rate accompanied with respiration and mediated by parasympathetic nerves. MWSA is in relation to periodical blood pressure variation (Mayer wave) and is mediated by both sympathetic and parasympathetic nerves. In many studies on HRV, the spectral powers of MWSA and RSA are named as LF (low frequency) and HF (high frequency) respectively. The ratio of LF/HF has been used as an index of human autonomic balance. However, the procedures for HRV measurements have not been validated. Especially, effect of the change of respiration should be considered which could affect not only on HF component, but also on LF component. We have developed three kind of computer software for the HRV measurement and analysis (real-time HRV monitoring system, analysis system for POLAR S-810 and long term HRV monitoring) with special reference to the effect of respiration. The characteristics and technical details of the systems and sample results of the measurement are shown in this report.