DEVELOPMENT OF A DEVICE FOR NITRIC OXIDE PRODUCTION USING PULSED DISCHARGES

开发利用脉冲放电生产一氧化氮的装置

• 批准号: 12557132
• 负责人: OKAMOTO Kazufumi
• 金额: $ 3.01万
• 依托单位: SHINSHU UNIVERSITY (2001-2002)Kumamoto University (2000)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12557132/
• 关键词: INHALED NITRIC OXIDE; PULSED POWER; ACUTE RESPIRATORY FAILURE; RESPIRATORY DISTRESS SYNDROME OF THE NEONATE; VENTILATOR; 呼吸不全; 人工呼吸; 二酸化窒素; 一酸化窒素; 肺高血圧

THE GOAL OF THE PRESENT STUDY WAS TO DEVELOPE A NOVEL DEVICE OF NITRIC OXIDE PRODUCTION USING PULSED DISCHARGES FOR INHALED NITRIC OXIDE THERAPY. A BRASS ELECTRODE WAS USED FOR DISCHARGE. ABOUT 400-500 PPM OF NITRIC OXIDE WAS PRODUCED. THE CONCENTRATION OF NITROGEN DIOXIDE WAS REDUCED USING MOLYBDENUM. BY USING CHARCOAL, THE CONCENTRATION OF NITROGEN DIOXIDE WAS MAINTAINED AT 0 PPM. SMALL AMOUNT OF NITROUS OXIDE WAS ALSO DETECTED. THE DEVICE LASTED 3 MONTHS WITHOUT ANY TROUBLE ALTHOUGH THE ABRASION OF THE ELECTRODE ffAS DETECTED. AN ELECTROMAGNETIC WAVE AND NOISE WERE WITHIN A PERMISSIBLE RANGE. FOR CLINICAL USE, WE HAVE TO CHECK MOREOVER IN DETAIL WHETHER ANYOTHER ABNORMAL GASES ARE NOT PRODUCED BY THE ELECTRICAL DISCHRGES. THE DEVICE CAN BE MINIATURIZED TO LOAD ON A VENTILATOR. INHALED NITRIC OXIDE THERAPY IS OFTEN USED FOR A NEONATE WITH HYPOXEMIC RESPIRATORY FAILURE. THE ANIMAL EXPERIMENT IS REQUIRED TO DETERMINE WHETHER INHALED NITRIC OXIDE THERAPY BY THE DEVICE DO NOT PRODUCE THE PATHOL OGICAL CHANGES OF THE LUNGS IN NEONATE ANIMALS.

本研究的目的是开发一种新型的利用脉冲放电产生一氧化氮的装置，用于吸入性一氧化氮治疗。放电采用黄铜电极。产生了大约400-500ppm的一氧化氮。使用钼降低了二氧化氮的浓度。通过使用木炭，二氧化氮浓度保持在0ppm。此外，亦检出少量一氧化二氮。虽然检测到了电极FFA的磨损，但该装置持续了3个月，没有任何故障。电磁波和噪音都在允许的范围内。临床使用时，还要详细检查是否有其他异常气体不是由电气设备产生的。该设备可以被微型化以加载到呼吸机上。吸入一氧化氮治疗常用于新生儿缺氧呼吸衰竭。需要进行动物实验，以确定该设备吸入一氧化氮治疗是否不会导致新生动物肺部的病理OGICAL变化。

项目成果

Namihira T, Katsuki S, Hackam R, Akiyama H, Okamoto K: "Production of nitric oxide using a pulsed are discharge"IEEE Transactions on Plasma Science. (In print).

Namihira T、Katsuki S、Hackam R、Akiyama H、Okamoto K：“使用脉冲电弧放电生产一氧化氮”IEEE 等离子体科学汇刊。

Okamoto K, et al: "Combination of inhaled nitric oxide therapy and IRV in patients with sepsis-associated ARDS."Artif Organs. 24・11. 902-908 (2000)

Okamoto K 等人：“脓毒症相关 ARDS 患者的吸入一氧化氮疗法和 IRV 的组合”。Artif Organs 24・11 (2000)。

Okamoto K, et al: "Combined effects of inhaled nitric oxide and positive end-expiratory pressure during CMD in ARDS."Artif Organs. 24・5. 390-395 (2000)

Okamoto K 等人：“ARDS 中 CMD 期间吸入一氧化氮和呼气末正压的综合影响”Artif Organs 24・5 (2000)。

浪平隆男, 勝木淳, 秋山秀典, 岡元和文: "パルスアーク放電プラズマによるNO生成と医療への応用"プラズマ・核融合学会誌. 79. 35-38 (2003)

Takao Namihira、Jun Katsuki、Hidenori Akiyama、Kazufumi Okamoto：“脉冲电弧放电等离子体产生 NO 及其医学应用”日本等离子体与核聚变学会杂志 79. 35-38 (2003)。

Namohira T, et al: "Production of nitric monoxide using pulsed discharges for a medical application"IEEE Transactions on Plasma Science. 28・1. 109-114 (2000)

Namohira T 等人：“使用脉冲放电生产一氧化氮用于医疗应用”IEEE Transactions on Plasma Science 28・1 (2000)。