PREVENTION OF ARDS BY INHALED NO AND DEVELOPMENT OF NO INHALATION SYSTEM WITHOUT USING NO STOCK TANK

通过吸入NO预防ARDS并开发不使用NO储罐的NO吸入系统

• 批准号: 09470333
• 负责人: OKAMOTO Kazufumi
• 金额: $ 5.57万
• 依托单位: KUMAMOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1997
• 资助国家: 日本
• 起止时间: 1997 至 1998
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-09470333/
• 关键词: ARDS; INHALED NITRIC OXIDE; NITRIC OXIDE INHALATION SYSTEM; PULSE POWER; 一酸化窒素; 呼吸不全; 肺高血圧; 急性呼吸窮迫症候群

THE MORTALITY OF PATIENTS 11TH ARDS ARE VERY HIGH.TO SAVE THE PATIENTS, WE MUST DEVELOP NEW THERAPEUTIC METHODS.FROM 1997 TILL 1998, INHALED NITRIC OXIDE WERE ADMINISTERED IN 34 PATIENTS WHO REQUIRED VENTILATOR THERAPY OF OVER F102 0.4. THE 800 PPM NITRIC OXIDE STOCK TANK WERE USED.TO CONTRAST, WE SELECTED A GROUP OF PATIENTS WHO HAD THE SAME SEVERITY OF DISEASES.WE COULD NOT FIND ANY IMPROVEMENTS OF MORTALITY BY INHALED NITRIC OXIDE.MOST PATIENTS DIED BY MULTIPLE ORGAN FAILURE.FURTHER STUDIES ARE REQUIRED.IN ADDITION, WE TRIED TO DEVELOP THE NEW DEVICE TO GENERATE NITRIC OXIDE.THE 100 NS PULSE POWER WERE ADDED TO THE MIXED GASES OF NITROGEN AND OXYGEN.THE AMOUNT OF NITRIC OXIDE GENERATION CHANGED BASED ON THE RATIO OF NITROGEN AND OXYGEN.THE AMOUNT OF GENERATED NITRIC OXIDE WAS HIGHEST WHEN THE RATIO OF NITROGEN/OXYGEN WERE AROUND 4/1. THE FREQUENCY AND ENERGY OF PULSE POWER AFFECTED TUE AMOUNT OF NITRIC OXIDE GENERATION.THE HIGHER AND STRONGER, THE AMOUNT OF GENERATED NITRIC OXIDE WAS HIGHER.SMALL AMOUNT OF NITRIC DIOXIDE WAS GENERATED ALSO.THIS NITRIC DIOXIDE WAS EASILY CONVERTED TO NITRIC OXIDE BY USING A HIGH TEMPERATURE (OVER 500 C) MOLYBDEM.THE STUDY IMPLIES THE POSSIBILlTY OF THE DEVELOPMENT OF A VENTILATOR WITH A NITRIC OXIDE GENERATOR.

1997年至1998年，我院应用一氧化氮吸入治疗34例F102 0.4以上呼吸机治疗的患者，均取得了较好的效果。使用800 PPM的一氧化氮储存罐。为了验证，我们选择了一组疾病严重程度较高的患者。我们没有发现吸入一氧化氮对死亡率有任何改善。大多数患者死于多器官功能衰竭。需要进一步研究。此外，我们尝试了一种新的产生一氧化氮的装置，在氮气和氧气的混合气体中加入100 NS的脉冲功率，根据氮氧比而变化。氮氧比为4/1左右时，一氧化氮的产生量最高。脉冲功率的频率和能量影响一氧化氮的产生量。脉冲功率越高、越强，一氧化氮的产生量越高，同时产生的一氧化氮也越少。这种一氧化氮很容易被高温（500 ℃以上）钼氧化物转化为一氧化氮。本研究暗示了研制一种带有一氧化氮发生器的呼吸机的可能性。

项目成果

Sato T,Okamoto K,Kukita I,Kikuta K,Hamaguchi M,Shiihara K,Shibata Y: "Nitrogen dioxide production in a nitric oxide inhalation system using Servo Ventilator 900C." Acta Paediatrica Japonica. 39 (2). 172-175 (1997)

Sato T、Okamoto K、Kukita I、Kikuta K、Hamaguchi M、Shiihara K、Shibata Y：“使用伺服呼吸机 900C 在一氧化氮吸入系统中产生二氧化氮。”

岡元和文,他: "NO吸入療法-ARDSの重症化予防法として-ICUとCCU" 23(印刷中). 1999.

Kazufumi Okamoto 等人：“NO 吸入疗法 - 作为预防 ARDS 恶化的方法 - ICU 和 CCU”1999 年。

岡元和文,他: "NO吸入療法-ARDSの重症化予防法として-" ICUとCCU. 23(印刷中). (1999)

Kazufumi Okamoto 等人：“NO 吸入疗法 - 作为预防 ARDS 恶化的方法”ICU 和 CCU（出版中）。

Sato T,Okamoto K,Shiihara K,Shibata Y,Kukita I,Kikuta K: "Nitrogen dioxide concentrations in a nitric oxide inhalation system using the Servo Ventilator 900C for pediatric respiratory failure." Kumamoto Medical Journal. 45 (4). 157-165 (1997)

Sato T、Okamoto K、Shiihara K、Shibata Y、Kukita I、Kikuta K：“使用伺服呼吸机 900C 治疗儿科呼吸衰竭的一氧化氮吸入系统中的二氧化氮浓度。”

岡元和文,他: "ARDSに対するNO吸入療法に未来はあるか?" 人工呼吸. 15(2). 111-114 (1998)

Kazufumi Okamoto 等人：“NO 人工呼吸治疗有未来吗？”111-114 (1998)。