Ultra-small doses of nitric oxide inhalation and oxygenation augmentation in severe respiratory failure

超小剂量一氧化氮吸入及增氧治疗严重呼吸衰竭

• 批准号: 07457360
• 负责人: OKAMOTO Kazufumi
• 金额: $ 3.07万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1995
• 资助国家: 日本
• 起止时间: 1995 至 1996
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07457360/
• 关键词: Nitric oxide; Respiratory failure; Pulmonary hypertension

In adults and children with acute respiratory distress syndrome, we found the followings : (1) ultra-small doses of inhaled nitric oxide (125-500 ppb) improved oxygenation, (2) an increase in oxygenation by inhaled nitric oxide correlated with the baseline PaO_2, (3) inhaled nitric oxide promoted carbon dioxide elimination, (4) optimal concentrations of inhaled nitric oxide were at or less than 2-4 ppm, and (5) the very small doses of inhaled nitric oxide produced a negligible amount of nitric dioxide and could be used for a few months without side effects. These findings established the safe measures of inhaled nitric oxide and showed the significance of the ultra-small doses of inhaled nitric oxide as a life-saving method for severe respiratory failure. In addition, we noticed that, to improve oxygenation by inhaled nitric oxide, nitric oxide must reach the alveoli and found that combined uses of inhaled nitric oxide and positive end-expiratory pressure along with inverse ratio ventilation improved oxygenation.

在患有急性呼吸窘迫综合征的成人和儿童中，我们发现：(1)超小剂量的吸入一氧化氮(125-500 ppb)可改善氧合，(2)吸入一氧化氮可增加氧合作用，与基线PaO2相关，(3)吸入一氧化氮可促进二氧化碳的消除，(4)吸入一氧化氮的最佳浓度为2-4ppm或以下，(5)极小剂量的吸入一氧化氮产生的二氧化氮可以忽略不计，可以连续使用几个月，没有副作用。这些发现确立了吸入一氧化氮的安全措施，并显示了超小剂量吸入一氧化氮作为救治严重呼吸衰竭的生命方法的重要性。此外，我们注意到，要通过吸入一氧化氮改善氧合，一氧化氮必须到达肺泡，并发现联合使用吸入一氧化氮和呼气末正压以及反比通风可以改善氧合。

项目成果

Shibata Y,Okamoto K,et al.: "The safety of nitric oxide inhalation using a conventional high frequency oscillatory ventilator" Acta Paediatrica Japonica. 39・(in press). (1977)

Shibata Y、Okamoto K 等人：“使用传统高频振荡呼吸机吸入一氧化氮的安全性”Acta Paediatrica Japonica 39·（出版中）。

岡元和文: "NOと病態-最新情報-" 中外医学社, 263 (1995)

Kazufumi Okamoto：“NO 和病理状况 - 最新信息 -”Chugai Igakusha，263 (1995)

Okamoto K,et al: "In haled nitric oxide for respiratory failure. (In Japanses)" Syuchyuchiryou. 8 (61). 607-614 (1996)

Okamoto K 等人：“吸入一氧化氮用于治疗呼吸衰竭。（日语）”Syuchuchiryou。

Kukita I,Okamoto,et al.: "Evaluation of Mapleson system for administration of inhaled NO." J Anesth. 10. 44-48 (1996)

Kukita I、Okamoto 等人：“用于吸入 NO 管理的 Mapleson 系统的评估”。

岡元和文,他: "呼吸不全に対するNO吸入療法" 集中治療. 8・6. 607-614 (1996)

Kazufumi Okamoto 等人：“呼吸衰竭的 NO 吸入疗法”重症监护 8・6（1996）。