With the aim of early convalescence of the occlusal function in the immediate implant after tooth extraction :

本研究的目的是将稀疏的松质骨致密，以达到拔牙后即刻种植体咬合功能的早期恢复。首先，我们开发了具有足够塑性的磷酸钙骨水泥，可以很容易地成型成所需的形状。该水泥具有良好的操纵性和生物相容性。此外，我们开发了夹层技术，并认为它对颌骨增大是有效的。虽然有可能使磷酸钙骨水泥具有多孔结构，但不可能开发出具有生物吸附能力的磷酸钙骨水泥。为了使松质骨致密化，有必要制备具有生物可吸收能力的骨水泥。因此，我们开发了可从14号针注射的β-TCP-CM-甲壳素复合材料。将该复合材料植入软组织和骨组织中，未见炎症反应。结果表明，该材料具有良好的生物相容性。植入BMP后，皮下组织中可见活跃的骨形成。在骨形态发生蛋白的载体上，通常采用胶原蛋白作为载体，但存在的问题也有报道。提示该复合材料适合作为骨形态发生蛋白的载体。组织学研究评估了该复合材料作为骨替代材料的有效性。植入后1周，材料表面可见活跃的骨形成。随着时间的推移，材料被吸收并被替换到骨组织中。松质骨致密化。提示拔牙后即刻种植体的咬合功能有早期恢复的可能。

The purpose of this study was to densify the sparse cancellous bone to achieve the early convalescence of the occlusal function in the immediate implant after tooth extraction. Firstly, we developed the calcium phosphate cement with the sufficient plasticity for easy molding into the desired shape. This cement had the good handling property and biocompatibility. Furthermore, we developed the sandwich technique and suggested that it was effective for the jaw bone augmentation. Although it was possible to make the calcium phosphate cement with porous structure, it was impossible to develop the calcium phosphate cement with bio-absorbability. It is necessary to make the cement with bio-absorbability for densification the cancellous bone. Therefore, we developed β-TCP-CM-chitin composite material that was injectable from the # 14 needle. No inflammatory response was observed when this composite was implanted in soft tissue and bone tissue. It showed this material had good biocompatibility. Active bone formation was observed in subcutaneous tissue when it was implanted with BMP. The problems such as BSE on the collagen are reported, while collagen was used for the carrier for BMP usual. It was suggested that this composite material was suitable for the carrier for BMP. Histological investigation was carried out to evaluate the effectiveness of this composite material as a bone substitute. At I week after implant, active bone formation was observed on the surface of the material. Absorption of the material and replacement to the bone was seen with time. It was showed that the cancellous bone was densified. These results suggested that the possibility of the early convalescence of the occlusal function in the immediate implant after tooth extraction.