With the aim of early convalescence of the occlusal function in the immediate implant after tooth extraction :

为了使拔牙后即刻种植体的咬合功能尽早恢复：

• 批准号: 12557162
• 负责人: YOKOYAMA Atsuro
• 金额: $ 5.57万
• 依托单位: HOKKAIDO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-12557162/
• 关键词: calcium phosphate cement; β-TCP; CM-chitin; BMP; cancellous bone; immediate implant; 骨補填材; オステオカルシン; ポリ乳酸; 多孔質; 遺伝子導入

The purpose of this study was to densify the sparse cancellous bone to achieve the early convalescence of the occlusal function in the immediate implant after tooth extraction. Firstly, we developed the calcium phosphate cement with the sufficient plasticity for easy molding into the desired shape. This cement had the good handling property and biocompatibility. Furthermore, we developed the sandwich technique and suggested that it was effective for the jaw bone augmentation. Although it was possible to make the calcium phosphate cement with porous structure, it was impossible to develop the calcium phosphate cement with bio-absorbability. It is necessary to make the cement with bio-absorbability for densification the cancellous bone. Therefore, we developed β-TCP-CM-chitin composite material that was injectable from the # 14 needle. No inflammatory response was observed when this composite was implanted in soft tissue and bone tissue. It showed this material had good biocompatibility. Active bone formation was observed in subcutaneous tissue when it was implanted with BMP. The problems such as BSE on the collagen are reported, while collagen was used for the carrier for BMP usual. It was suggested that this composite material was suitable for the carrier for BMP. Histological investigation was carried out to evaluate the effectiveness of this composite material as a bone substitute. At I week after implant, active bone formation was observed on the surface of the material. Absorption of the material and replacement to the bone was seen with time. It was showed that the cancellous bone was densified. These results suggested that the possibility of the early convalescence of the occlusal function in the immediate implant after tooth extraction.

本研究的目的是在拔牙后即刻种植体中，使稀疏的松质骨致密化，以达到咬合功能的早期恢复。首先，我们开发了具有足够可塑性的磷酸钙骨水泥，易于成型为所需形状。该骨水泥具有良好的操作性能和生物相容性。此外，我们发展了三明治技术，并建议它是有效的颌骨增量。虽然制备多孔结构的磷酸钙骨水泥是可能的，但开发具有生物可吸收性的磷酸钙骨水泥是不可能的。为了使松质骨致密化，需要制备具有生物可吸收性的骨水泥。因此，我们开发了β-TCP-CM-甲壳素复合材料，可从#14针注射。当该复合材料植入软组织和骨组织时，未观察到炎症反应。表明该材料具有良好的生物相容性。植入BMP后，皮下组织中骨形成活跃。报道了胶原蛋白作为骨形态发生蛋白载体时，存在的问题，如牛海绵状脑病等。表明该复合材料适合作为骨形态发生蛋白的载体。进行组织学研究以评价该复合材料作为骨替代物的有效性。植入后1周，在材料表面观察到活跃的骨形成。随着时间的推移，观察到材料吸收和骨置换。结果显示松质骨致密化。结果提示拔牙后即刻种植牙有可能使咬合功能早期恢复。

项目成果

A.Yokoyama, H.Matsuno, S.Yamamoto, T.Kawasaki, T.Kohgo, M.Uo, F.Watari, M.Nakasu: "Tissue response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl-chitin"J Biomed Mater Res. 64A. 491-501 (2003)

A.Yokoyama、H.Matsuno、S.Yamamoto、T.Kawasaki、T.Kohgo、M.Uo、F.Watari、M.Nakasu：“对新开发的含有琥珀酸和羧甲基甲壳素的磷酸钙水泥的组织反应”

R.Fujita, A.Yokoyama, T.Kawasaki, T.Kohgo: "Bone augmentation osteogenesis using hydroxyapatite and β-tricalcium phosphate blocks"J Oral Maxillofac Surg. 61. 1045-1053 (2003)

R.Fujita、A.Yokoyama、T.Kawasaki、T.Kohgo：“使用羟基磷灰石和 β-磷酸三钙块进行骨增强成骨”J Oral Maxillofac Surg。 61. 1045-1053 (2003)

Fujita R, Yokoyama A, Kawasaki T, Kohgo T.: "Bone augmentation osteogenesis using hydroxy-apatite and β-tricalcium phosphate blocks."J Oral Maxillofac Surg. 61. 1045-1053 (2003)

Fujita R、Yokoyama A、Kawasaki T、Kohgo T.：“使用羟基磷灰石和 β-磷酸三钙块进行骨增强成骨。”J Oral Maxillofac Surg。 61. 1045-1053 (2003)

Ohori K, Yokoyama A, Kawasaki T, Iizuka T, Kohgo T.: "Effect of non-resorbable membrane on bone formation after implant of apatite blocks on bone."J Jpn Prosthodont Soc. 46. 712-721 (2002)

Ohori K、Yokoyama A、Kawasaki T、Iizuka T、Kohgo T.：“在骨上植入磷灰石块后不可吸收膜对骨形成的影响。”Jpn Prosthodont Soc。

Yokoyama A, Matsuno H, Yamamoto S, Kawasaki T, Kohgo T, Uo M, Watari F, Naksu M: "Tissue response to a newly developed calcium phosphate cement containing succinic acid and carboxymethyl-chitin."J Biomed Mater Res. 64A. 491-501 (2003)

Yokoyama A、Matsuno H、Yamamoto S、Kawasaki T、Kohgo T、Uo M、Watari F、Naksu M：“对新开发的含有琥珀酸和羧甲基甲壳素的磷酸钙水泥的组织反应。”J Biomed Mater Res。