Development of implant biomaterials for human body by a new method using two excimer lasers

利用两种准分子激光器的新方法开发人体植入生物材料

• 批准号: 13450301
• 负责人: NAKAYAMA Takeyoshi
• 金额: $ 3.07万
• 依托单位: Kinki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13450301/
• 关键词: Laser ablation; LALA method; Surface modification; Biocompatible materials; Hydroxyapatite; Titanium; Ceramics; Alumina; レーザー照射

The aim of this project is the development of a biocompatible material that is implanted in living human body by using excimer laser irradiation method.The results obtained in this project are as follows ;A.Development of biocompatible material(1)Formation of hydroxyapatite(HAp) layer on Al_2O_3 substrate by excimer laser irradiation method was achieved.(2)Formation of a new bone on the surface of the above-mentioned sample was observed when the sample was immersed in stimulated body fluid(SBF) for 2 weeks.B.Effect of crystalline condition of HAp target on coating layerGrowth of HAp coating layer in SBF has been observed only when the slab crystal target was used.C.Development of a new method for HAp coating on biocompatible materials(1)The laser assisted-laser ablation(LALA) method was developed by using KrF and ArF excimer lasers.(2)High quality hydroxyapatite coating was obtained by control the irradiation timing of assist laser.These results were reported in the international conference of APLS'2000(invited), FSE2001,IMLAS'03,COLA'03 and many domestic conferences.

The aim of this project is the development of a biocompatible material that is implanted in living human body by using excimer laser irradiation method.The results obtained in this project are as follows ;A.Development of biocompatible material(1)Formation of hydroxyapatite(HAp) layer on Al_2O_3 substrate by excimer laser irradiation method was achieved.(2)Formation of a new bone on the surface当将样品浸入刺激的体液（SBF）中2周时，观察到上述样品的样品。通过使用KRF和ARF进取激光制定消融方法。（2）高质量的羟基磷灰石涂层是通过对照辅助激光的照射时间获得的。这些结果在APLS'2000国际会议上（被邀请），FSE2001，IMLAS'03，COLA'03，COLA'03和许多家用代表。

项目成果

M.Katto, M.Nakamura, T.Tanaka, T.Matsutani, M.Kuwata: "Hydroxyapatite coatings using novel pulsed laser ablation methods"Surface and Coatings Technology. 169/170. 712-715 (2003)

M.Katto、M.Nakamura、T.Tanaka、T.Matsutani、M.Kuwata：“使用新型脉冲激光烧蚀方法的羟基磷灰石涂层”表面和涂层技术。

甲藤正人, 黒沢宏, 中山斌義, 塚本雅裕, 瀧川靖雄, 高橋健治: "パルスレーザー堆積法による機能性材料皮膜の形成-構造制御と基礎課程の解明に向けて-"レーザー学会第317回研究会報告. RTM-03-44. 37-42 (2003)

Masato Koto、Hiroshi Kurosawa、Yasuyoshi Nakayama、Masahiro Tsukamoto、Yasuo Takikawa、Kenji Takahashi：“通过脉冲激光沉积形成功能材料薄膜 - 实现结构控制和基本过程的阐明 -”激光协会第 317 届研究会议报告。 -44。37-42（2003）

M.Katto, H.Kurosawa, T.Nakayama, M.Tsukamoto, Y.Takikawa, K.Takahashi: "Films and coatings of functional materials made by pulsed laser deposition, towards crystalline-controlled deposition and observation of its initial state(in Japanese)"Report on the 3

M.Katto、H.Kurosawa、T.Nakayama、M.Tsukamoto、Y.Takikawa、K.Takahashi：“通过脉冲激光沉积制备功能材料的薄膜和涂层，以实现晶体控制沉积并观察其初始状态（在

中山 斌義 他9名: "レーザー血行再建術(「循環器科」特別増刊号、第3章分担執筆)"科学評論社. 170(25) (2003)

Binyoshi Nakayama等9人：“激光血运重建（心脏病学特刊，合着第3章）” Kagaku Hyoronsha 170（25）（2003）。

T.Nakayama, M.Kuwata, T.Matsutani: "New hydroxyapatite coating method for biocompatible material"Chinese Journal of Lasers. B10 Suppl.. VI1-VI6 (2001)

T.Nakayama、M.Kuwata、T.Matsutani：“生物相容性材料羟基磷灰石涂层新方法”中国激光杂志。