Development of hybrid implant biomaterials by excimer laser irradiation and study on laser-tissue interaction mechanism

The aims of this project are (1) Development of a biocompatible material which is implant in vinghuman body by using excimer laser irradiation method and (2) Elucidation of laser light-tissueinteraction mechanism.The results obtained in this project are as follows；A. Development of biocompatible material(1) Formation of hydroxyapatite (HAp) layer onD22 D2O D23 D2 substrate by excimer laser irradiation method was achieved.(2) Formation of anew bone on the surface of the above-mentioned sample was观察when the sample was immersed instimulated body fluid (SBF) for 2 weeks.(3) A new laser irradiation method was developed for HApcoating on Ti.B. Laser lighttissue interaction mechanism.(1) The difference between KrF和ArF外科手术laser irradiation effect for soft tissue explained through the spectroscopic study.(2)Mechanism of laser ablation for hard tissue was elucidated by time-resolved photography。

The aims of this project are (1) Development of a biocompatible material which is implant in living human body by using excimer laser irradiation method and (2) Elucidation of laser light-tissue interaction mechanism.The results obtained in this project are as follows ;A. Development of biocompatible material(1) Formation of hydroxyapatite (HAp) layer on AlィイD22ィエD2OィイD23ィエD2 substrate by excimer laser irradiation method was achieved.(2) Formation of a new bone on the surface of the above-mentioned sample was observed when the sample was immersed in stimulated body fluid (SBF) for 2 weeks.(3) A new laser irradiation method was developed for HAp coating on Ti.B. Laser light-tissue interaction mechanism.(1) The difference between KrF and ArF excimer laser irradiation effect for soft tissue was explained through the spectroscopic study.(2) Mechanism of laser ablation for hard tissue was elucidated by time-resolved photography.