Development of hybrid implant biomaterials by excimer laser irradiation and study on laser-tissue interaction mechanism

该项目的目的是（1）开发一种利用准分子激光照射方法植入活体人体的生物相容性材料；（2）阐明激光光-组织相互作用机制。该项目获得的结果如下；A．生物相容性材料的研制(1)通过准分子激光辐照方法在AliD22D2OiD23D2基底上实现了羟基磷灰石(HAp)层的形成。(2)将样品浸入刺激体液(SBF)中2周后观察到上述样品表面形成新骨。(3)开发了一种新的激光辐照方法在Ti.B上涂覆HAp。激光光-组织相互作用机制。(1)通过光谱研究解释了KrF和ArF准分子激光对软组织照射效果的差异。(2)通过时间分辨摄影阐明了激光消融硬组织的机理。

The aims of this project are (1) Development of a biocompatible material which is implant in living human body by using excimer laser irradiation method and (2) Elucidation of laser light-tissue interaction mechanism.The results obtained in this project are as follows ;A. Development of biocompatible material(1) Formation of hydroxyapatite (HAp) layer on AlィイD22ィエD2OィイD23ィエD2 substrate by excimer laser irradiation method was achieved.(2) Formation of a new bone on the surface of the above-mentioned sample was observed when the sample was immersed in stimulated body fluid (SBF) for 2 weeks.(3) A new laser irradiation method was developed for HAp coating on Ti.B. Laser light-tissue interaction mechanism.(1) The difference between KrF and ArF excimer laser irradiation effect for soft tissue was explained through the spectroscopic study.(2) Mechanism of laser ablation for hard tissue was elucidated by time-resolved photography.