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The epidemiological study regarding the gene-lifestyle interaction on hypertension

高血压基因与生活方式相互作用的流行病学研究

基本信息

批准号：
13470085
负责人：
TSUJI Ichiro
金额：
$ 10.37万
依托单位：
Tohoku University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13470085/
关键词：
Hypertension Community based study Ambulatory blood pressure Home blood pressure Gene polymorphisms Lifestyle Circulatory disease epidemiology Risk factors

项目摘要

We investigated the relationship between gene polymorphisms and blood pressure (BP), especially BP measured at home (home EP, HBP) or ambulatory BP (ABP), using blood sample obtained from Ohasama residents. We showed the summary of articles which was published in last year.1)Heat rate and outcome.This review article summarizes the reports which investigated the relationship between heart rate (HR) and cardiovascular outcomes in Ohasama residents. Home measured HR linearly related to the cardiovascular disease mortality, while HR variability measured by device for ABP inversely related to the cardiovascular mortality. HR and HR variability must not be overlooked when evaluating hypertension.2)Gene polymorphisms of rennin-angiotensin system and blood pressure.The angiotensinogen gene polymorphisms (AGT) M235T has been investigated in association with essential hypertension based on conventional measurement of BP ; however, the results have been inconsistent. We investigated the relationship between AGT and HBP value. There was no significant difference among the genotypes in home BP values or in prevalence of hypertension. No difference was noted in the frequency of familial history of hypertension. Pulse pressure, however, was significantly different among the genotypes (P=0.049), and this association was prominent in the older population (Paper 2).We also investigated the relationship between the angiotensin II type 1 receptor (AT1) gene and ABP. We investigated 802 subjects who were 40 years or over. Although daytime BP was higher in subjects with C allele, the difference was not statistically significant after adjusting possible confounders. No significant difference was noted in the prevalence of cardiovascular diseases of nocturnal decline between the groups. These results indicated that AT1 polymorphism was not associated with any clinical parameters associated with hypertension or atherosclerosis in the Japanese (Paper 3).

本研究以大阪居民的血样为样本，研究了基因多态性与血压的关系，特别是在家中测得的血压(家中的EP，HBP)和动态血压(ABP)。我们展示了去年发表的文章摘要1)热率和结果。这篇综述文章总结了研究大阪居民心率(HR)和心血管结果之间关系的报道。家庭测量的心率与心血管疾病死亡率呈线性相关，而用ABP装置测量的心率变异性与心血管疾病死亡率呈负相关。在评价高血压时，心率和心率变异性不容忽视。2)肾素-血管紧张素系统基因多态性与血压。血管紧张素原基因多态性(AGT)M235T已在常规测量血压的基础上被研究与高血压相关；然而，结果并不一致。我们研究了AGT与HBP之间的关系。家庭血压和高血压患病率不同基因型间差异无统计学意义。高血压家族史的出现频率无明显差异。然而，脉压在不同的基因型间有显著差异(P=0.049)，这种关联在老年人群中显著(文献2)。我们还调查了血管紧张素II 1型受体(AT1)基因与动脉血压的关系。我们调查了802名40岁及以上的受试者。尽管携带C等位基因的受试者白天血压较高，但在调整可能的混杂因素后，这种差异在统计学上并不显著。两组之间夜间下降的心血管疾病的患病率没有显著差异。这些结果表明，在日本，AT1基因多态与任何与高血压或动脉粥样硬化相关的临床参数无关(论文3)。