Molecular epidemiological research on development and progression of asymptomatic cerebral infarction.

我们研究了四个候选基因多态性之间的关系，即，血管紧张素转换酶（ACE I或D）、血管紧张素原（AGT）/M235 T、血管紧张素II 1型受体（AT 1）/A1166 C和2型受体（AT 2）/C3123 A以及腔隙性脑梗死的严重程度。本研究阐明AGT和AT 1基因多态性是腔隙性脑梗死的独立遗传危险因素，并探讨了高血压相关基因多态性，即人G蛋白β3亚基（GNB 3/C825 T）和上皮Na+通道（ENaC/T594 M，P592 S）与家庭血压值或高血压患病率。我们没有发现这些多态性与家庭血压值或高血压患病率之间存在显著关联。我们研究了短期和长期血压变异的预后意义。短期血压变异性计算为通过动态血压测量测量的日间或夜间血压的SD。同样，长期血压变异性计算为通过家庭血压测量测量的血压值的SD。这些变异性与心血管死亡率独立相关，即使我们调整了几个混杂因素。

We investigated the relationships between four candidate gene polymorphisms, i.e., angiotensin-converting enzyme (ACE I or D), angiotensinogen (AGT)/M235T, angiotensin II type 1 receptor (AT1)/A1166C and type 2 receptor (AT2)/C3123A, and the severity of lacunar Infarction. The study clarified that AGT and AT1 polymorphisms are Independent genetic risk factors for lacunar Infarction.We also investigated the relationships between hypertension related gene polymorphisms, i.e., human G protein β3 subunit (GNB3/C825T) and epithelial Na+ channel (ENaC/T594M, P592S), and home blood pressure value or prevalence of hypertension. We did not found significant association between these polymorphisms and home blood pressure value or prevalence of hypertension.We investigated the prognostic significance of both short-term and long-term blood pressure variabilities. Short-term blood pressure variability was calculated as SD of daytime or nighttime blood pressure measured by ambulatory blood pressure measurement. Similarly, long-term blood pressure variability was calculated as SD of blood pressure values measured by home blood pressure measurement. These variabilities are independently related to the cardiovascular mortality even though we adjusted for several confounding factors.