Evaluation of the jaw and periodontal tissues induced hy ovariectomy in the cynomolgus monkeys with osteoporosis.

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Objectives:The purpose of this study was to assess the change of the jaw and periodontal tissues after ovariectomy in monkeys.Methods:Forty-two cynomolgus monkeys with estimated age of 9 to 15 years were divided into two groups : a group that underwent ovariectomy (OVX group, n=2l) and a sham-operated group (SHAM group, n=21). Two years after the operation, the animals mere killed, and the maxillo-facial bones mere dissected. Each bone was examined with cepharogram, CT, micro-CT, soft X-ray, and periapical radiograph.Results:(1)In densitometric analysis of cephalogram, the OVX group showed a significant decrease in the bone mineral contents (BMCs) of the alveolar bone and the marginal bone of the mandibular angle.(2)The OVE group showed a significant decrease in CT value of mandibular condyle.(3)In the BMG of mandibular body on soft X-ray film, a significant difference was not observed between OVX and Sham groups.(4)In morphological analysis of temporomandibular joint (TMJ), a significant difference was not observed between OVX and Sham groups.(5)On periapical radiograph, a significant difference was not observed in the thickness of the lamina dura and periodontal space.(6)On micro-CT of TMJ, the OVE group showed a significant decrease in bone volume fraction, trabecular number, and trabecular thickness of the trabecular bone in the condyle and mandibular fossa.