A genetic mode of regulation for the growth correlation of mandible and craniomaxilla

下颌骨和颅下颌骨的生长相关性对于物种的形态、行为和颅功能的遗传是必不可少的。本研究的目的是证明一种遗传模式的调节生长相关的下颌骨和颅下颌骨。为了确定相关性的遗传联系，我们分析了由MRL/Mp两种不同菌株产生的F2杂交小鼠的遗传变异。Faslpr-rpl/rpl （MRL/rpl）和C3H/HeJ。Faslpr(摘要/ lpr)。所有小鼠在20周龄时进行下颌骨和颅下颌骨形态学测量。采用247只F2杂交小鼠在96个微卫星位点对下颌骨和颅下颌骨的形态学指标进行了全基因组遗传分析。研究结果总结如下：1。雌雄小鼠的下颌骨宽度指标差异显著。2. 上颌下颌区（MMR）的形态变异与位于D1Mit46 （chr）附近的几个遗传位点显著相关。1), D10Mitl64 (chr。和D11Mit263 （chr. 10）。11)。3. MMR的形态变化主要依赖于下颌宽度的变化。4. 作为与chr相关的职位候选人。1个位点，指出了编码胰岛素样生长因子结合蛋白的基因（IGFBP2和5）。综上所述，小鼠模型表明MMR的形态在多基因遗传模式下受到控制。目前，IGFBP2或5被认为是影响MMR形态的遗传因子的位置候选者。

A growth correlation of mandible and craniomaxilla is essential for the inheritance of morphology, behavior, and cranial function of a species. The aim of this study is to demonstrate a genetic mode of regulation for the growth correlation of mandible and craniomaxilla. To identify a genetic link of the correlation, we analyzed genetically varied intercross F2 mice, which were generated from two different strains of mice, MRL/Mp.Faslpr-rpl/rpl (MRL/rpl) and C3H/HeJ.Faslpr (C3H/lpr). Morphological measurements for mandible and craniomaxilla were performed at 20 weeks of age for all mice. A genome-wide genetic analysis for the morphological indexes of mandible and craniomaxilla was performed using 247 F2 intercross mice at 96 microsattelite loci. The results are summarized as follows: 1. The indexes of mandibular width were highly, significantly different between male and female mice. 2. The morphological variation of maxillo-mandibular region (MMR) was significantly associated with several genetic loci, which were located in the vicinity of D1Mit46 (chr. 1), D10Mitl64 (chr. 10), and D11Mit263 (chr. 11). 3. The morphological variation of MMR was largely dependent on those in mandibular width. 4. As positional candidates associated with the chr. 1 locus, the genes encoding insulin-like growth-factor-binding proteins (IGFBP2 and 5) were pointed out.In conclusion, the mouse model indicates that the morphology of MMR is controlled under the polygenic mode of inheritance. Presently, either of IGFBP2 or 5 was suggested to be a positional candidate for a genetic factor that affects the morphology of MMR.