An experimental study for a novel gene therapy for the highly malignant tumor of salivary gland using nanobubbles and ultrasound

本研究的目的是建立一种新的诊断和基因治疗系统的高度恶性涎腺肿瘤，利用纳米气泡和超声。在本研究中，通过使用实验肿瘤模型，我们开发了一种利用纳米气泡和高频超声图像分析设备的高分辨率诊断成像系统。此外，我们能够提出一种新的基因治疗方法的可能性，通过利用纳米气泡和超声波转移质粒DNA，抑制肿瘤生长。

The aim of the present study is to develop a novel diagnosis and gene therapy system for the highly malignant tumor of salivary gland using nanobubbles and ultrasound. In the present study, by using experimental tumor model, we developed a high-resolution diagnostic imaging system utilizing nanobubbles and high-frequency ultrasound image analysis equipment. In addition, we were able to present the possibility of a new gene therapy method by transfer of a plasmid DNA, which inhibited the tumor growth, by utilizing nanobubbles and ultrasound.