Construction of Molecular Devise using Metal Complex-type Artificial DNA 60187333

DNA具有排列功能化构建块的结构基础。在这项研究中，一到五个由Cu^&lt；2+和gt；介导的碱基对被系统地结合到DNA双链的中间，通过堆积在DNA螺旋中的单核到五核Cu^&lt；2+&gt；络合物的排列形成了一条磁链。每个络合物中的Cu2+离子通过未配对的d电子相互铁磁耦合。提出了一种DNA中含有Cu^&lt；2+&gt；阵列的右旋双链结构的轮廓，其中Cu^&lt；2+&gt；-Cu^&lt；2+&gt；距离与自然碱基对之间的距离几乎相同。这一策略代表了一种以离散和可预测的方式在溶液中排列金属离子的新方法，并与其他方法的非生物方法形成了对比，从而导致了分子磁体和金属丝等基于金属的分子器件的可能性。

DNA has a structural basis to array functionalized building blocks. In this study, one to five Cu^<2+>-mediated base pairs of hydroxypyridone nucleobases have been systematically incorporated into the middle of a DNA duplex, resulting in the formation of a magnetic chain by the line-up of mono- to pentanuclear Cu^<2+> complexes stacked within the DNA helix. The Cu^<2+> ions in each complex couple ferromagnetically with one another through unpaired d electrons. An outline of a right-handed, double-stranded structure with Cu^<2+> array inside the DNA is proposed, where the Cu^<2+>-Cu^<2+> distance is almost the same as that between natural base pairs. This strategy represents a new method for arranging metal ions in solution in a discrete and predictable fashion and contrasts with the non-biological approach of others, leading to the possibility of metal-based molecular devices such as molecular magnets and wires.