Construction of Molecular Devise using Metal Complex-type Artificial DNA 60187333

使用金属络合物型人工DNA构建分子装置 60187333

• 批准号: 13554024
• 负责人: TANAKA Kentaro
• 金额: $ 9.15万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13554024/
• 关键词: Artifical DNA; Metal Complex; Self-Assebmly; Nucleoside; Oligonuclentide; DNA; 核酸塩基; 遺伝子; ピリジン

DNA has a structural basis to array functionalized building blocks. In this study, one to five Cu^<2+>-mediated base pairs of hydroxypyridone nucleobases have been systematically incorporated into the middle of a DNA duplex, resulting in the formation of a magnetic chain by the line-up of mono- to pentanuclear Cu^<2+> complexes stacked within the DNA helix. The Cu^<2+> ions in each complex couple ferromagnetically with one another through unpaired d electrons. An outline of a right-handed, double-stranded structure with Cu^<2+> array inside the DNA is proposed, where the Cu^<2+>-Cu^<2+> distance is almost the same as that between natural base pairs. This strategy represents a new method for arranging metal ions in solution in a discrete and predictable fashion and contrasts with the non-biological approach of others, leading to the possibility of metal-based molecular devices such as molecular magnets and wires.

DNA具有阵列功能化构建块的结构基础。在这项研究中，一到五个Cu^<2+>介导的羟基吡啶酮核碱基对被系统地纳入DNA双链的中间，通过在DNA螺旋内堆积的单核到五核Cu^<2+>络合物形成磁链。每个络合物中的Cu^<2+>离子通过未配对的d电子以铁磁方式相互耦合。提出了DNA内具有Cu^<2+>阵列的右手双链结构的轮廓，其中Cu^<2+>-Cu^<2+>的距离与自然碱基对之间的距离几乎相同。这种策略代表了一种以离散和可预测的方式在溶液中排列金属离子的新方法，与其他非生物方法形成对比，导致金属基分子器件（如分子磁铁和分子线）的可能性。

项目成果

K. Tanaka, A. Tengeiji, T. Kato, N. Toyama, and M. Shionoya: "A Discrete Self-Assembled Metal Array in Artificial DNA"Science. 299. 1212-1213 (2003)

K. Tanaka、A. Tengeiji、T. Kato、N. Toyama 和 M. Shionoya：“人工 DNA 中的离散自组装金属阵列”科学。

M. Tasaka, K. Tanaka, M. Shiro, and M. Shionoya: "Toward Nano-Assembly of Metals through Engineered DNAs"Supramolecular chemistry. 13. 255-261 (2002)

M. Tasaka、K. Tanaka、M. Shiro 和 M. Shionoya：“通过工程 DNA 实现金属纳米组装”超分子化学。

K.Tanaka, Y.Yamada, M.Shionoya: "Formation of Silver(I)-Mediated DNA Duplex and Triplex through an Alternative Base Pair of Pyridine Nucleobases"Journal of the American chemical society. 124. 8802-8803 (2002)

K.Tanaka、Y.Yamada、M.Shionoya：“通过吡啶核碱基的替代碱基对形成银 (I) 介导的 DNA 双链体和三链体”美国化学会杂志。

K. Tanaka, Y. Yamada, and M. Shionoya: "Formation of Silver(I)-Mediated DNA Duplex and Triplex through an Alternative Base Pair of Pyridine Nucleobases"Journal of the American chemical society. 124. 8802-8803 (2002)

K. Tanaka、Y. Yamada 和 M. Shionoya：“通过吡啶核碱基的替代碱基对形成银 (I) 介导的 DNA 双链体和三链体”美国化学会杂志。

S.Aketani, K.Tanaka, K.Yamamoto, A.Ishihama, H.Cao, A.Tengeiji, S.Hiraoka, M.Shiro, M.Shionoya: "Syntheses and Structure-Activity Relationships of Nonnatural β-C-Nucleoside 5'-Triphosphates Bearing an Aromatic Nucleobase with Phenolic Hydroxyl Groups : In

S.Aketani、K.Tanaka、K.Yamamoto、A.Ishihama、H.Cao、A.Tengeiji、S.Hiraoka、M.Shiro、M.Shionoya：“非天然 β-C-核苷的合成和构效关系带有酚羟基的芳香核碱基的 5-三磷酸酯 : In