Construction of Molecular Devise using Metal Complex-type Artificial DNA 60187333

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DNA has a structural basis to array functionalized building blocks. In this study, one to five Cu^<2+>-mediated base pairs of hydroxypyridone nucleobases have been systematically incorporated into the middle of a DNA duplex, resulting in the formation of a magnetic chain by the line-up of mono- to pentanuclear Cu^<2+> complexes stacked within the DNA helix. The Cu^<2+> ions in each complex couple ferromagnetically with one another through unpaired d electrons. An outline of a right-handed, double-stranded structure with Cu^<2+> array inside the DNA is proposed, where the Cu^<2+>-Cu^<2+> distance is almost the same as that between natural base pairs. This strategy represents a new method for arranging metal ions in solution in a discrete and predictable fashion and contrasts with the non-biological approach of others, leading to the possibility of metal-based molecular devices such as molecular magnets and wires.