Design of neural prosthetic system for lost sensory functions using microelectrode arrays

使用微电极阵列设计丧失感觉功能的神经假体系统

• 批准号: 13555039
• 负责人: MATSUMOTO Kiyoshi
• 金额: $ 8.58万
• 依托单位: The University of Tokyo
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13555039/
• 关键词: Auditory Brainstem Implant; Neural Prosthesis; Auditory Cortex; Cochlear Nucleus; Spinal Cord; Nerve Equation; Independent Component Analysis; Functional Stimulation; 脳機能マッピング; 機能構造; 微小多点電極; 電気刺激; 誘発電位; 神経細胞モデル

The objective of the present study is to establish design guidelines for developing neural prosthesis that restores lost sensory functions due to disorders of sensory cells or pathways. The achievements of the study are summarized as follows. First, we developed an experimental animal model of the auditory brainstem implant (ABI) that directly stimulates the cochlear nucleus in the brainstem to restore the hearing of deaf patients who had their auditory nerves removed. The model included a surface microelectrode array for auditory cortical recording and a spike microelectrode arrray for the microstimulation in the cochlear nucleus. Second, using the ABI model of rats, we demonstrated that the cochlear nuclear microstirnulation could evoke spatio-temporal neural activity in the auditory cortex and the proper stimulation could take after the pure-tone-evoked activation, suggesting that the stimulation could induce a pitch and intensity sensation and thus substantially verifying the capab … More ility of ABI Third, we proposed and verified "the multiple gating stimulation," which can selectively activate nerves placing in between electrodes. The technique broadly generated action potentials with "the cathodic sourte electrodes," and simultaneously blocked unnecessary propagation with "the anodic gate electrodes," resulting in selective propagation in between electrodes. We demonstrated the feasibility via simulations with nerve equations and in vivo experiments of rat spinal cord stimulation Forth, our cortical auditory evoked potential (AEP) mapping demonstrated that the rat auditory cortex is divided into the multiple auditory fields, which represent the information of test tones in their respective manner. Fifth, we combined theoretical and experimental works to better understand the spatio-tempomal neuronal activation. We interpreted the contradictory MLR neurogenesis and their various morphologies particularly within early latency, and finally suggested that they were determined by combination of three activities: cortical firing activities, cortical synaptic activities, and other activities far from cortex. Less

本研究的目的是建立神经假体的设计指南，以恢复由于感觉细胞或通路紊乱而失去的感觉功能。本文的研究成果总结如下：首先，我们建立了听觉脑干植入（ABI）的实验动物模型，该模型直接刺激脑干中的耳蜗核，以恢复听神经切除的失聪患者的听力。该模型包括用于听觉皮层记录的表面微电极阵列和用于耳蜗核微刺激的尖峰微电极阵列。其次，利用大鼠的ABI模型，我们证明了耳蜗核微刺激可以引起听觉皮层的时空神经活动，并且在纯音诱发激活之后可以进行适当的刺激，这表明刺激可以引起音高和强度的感觉，从而从本质上验证了ABI的能力。它可以选择性地激活电极之间的神经。该技术通过“阴极源电极”广泛产生动作电位，同时通过“阳极栅电极”阻止不必要的传播，从而导致电极之间的选择性传播。通过神经方程模拟和大鼠脊髓刺激体内实验验证了该方法的可行性。第四，我们的皮层听觉诱发电位（AEP）图谱表明，大鼠听觉皮层被划分为多个听觉场，这些听觉场以各自的方式代表着测试音调的信息。第五，我们将理论与实验相结合，以更好地了解时空神经元的激活。我们解释了MLR神经发生的矛盾及其各种形态，特别是在早期潜伏期，最后提出它们是由三种活动的结合决定的：皮层放电活动、皮层突触活动和其他远离皮层的活动。少

项目成果

岡野雄一郎, 他: "神経外からの多点同時刺激に対する神経束の挙動のシミュレーション"第18回生体・生理工学シンポジウム講演論文集. 177-180 (2003)

Yuichiro Okano 等人：“模拟神经束响应来自神经外部的同时多点刺激的行为”第 18 届生物和生理工程研讨会论文集 177-180 (2003)。

Hirokazu TAKAHALSHI, Takayuki EJIRI, Fumio MASE, Masayuki NAKAO, Yotaro HATAMURA, Naoya NAKAMURA, Kimitaka KAGA, Thierry HERVE: "Surface Microelectrode and Spike Microelectrode Array for Measuring Neuronal Activities"Proceedings of SICE 2001. 110D-2(CD-RO

Hirokazu TAKAHALSHI、Takayuki EJIRI、Fumio MASE、Masayuki NAKAO、Yotaro HATAMURA、Naoya NAKAMURA、Kimitaka KAGA、Thierry HERVE：“用于测量神经元活动的表面微电极和尖峰微电极阵列”SICE 2001年论文集。110D-2（CD-RO）

Hirokazu Takahashi, Takayuki Ejiri, Masayuki Nakao, Naoya Nakamura, Kimitaka Kaga, Thierry Herve: "Microelectrode Array on Folding Polyimide Ribbon for Epidural Mapping of Functional Evoked Potentials"IEEE Transactions on Biomedical Engineering. 50. 510-5

Hirokazu Takahashi、Takayuki Ejiri、Masayuki Nakao、Naoya Nakamura、Kimitaka Kaga、Thierry Herve：“折叠聚酰亚胺带上的微电极阵列，用于硬膜外功能诱发电位的映射”IEEE 生物医学工程汇刊。

Takahashu H, Nakao M, Ejiri T, Kaga K: "Different strategies for intensity coding in different cortical anditory fields"Proceedingx of the International Conferece on Auditory, Cortex. 67 (2003)

Takahashu H、Nakao M、Ejiri T、Kaga K：“不同皮质和听觉领域强度编码的不同策略”国际听觉皮层会议论文集。

高橋宏知: "音刺激および電気刺激に対する誘発電位の多点同時計測による聴皮質の機能解明"医学のあゆみ. 200・2. 192-193 (2002)

Hirotomo Takahashi：“通过同时多点测量响应声音和电刺激的诱发电位来阐明听觉皮层的功能”医学史200・2（2002）。