Establishment of a new inbred strain rat developing spontaneous eosinohilia (MES) and investigation of the pathogenesis.

我们的研究结果如下：1)建立了一种全新的自发性嗜酸性粒细胞增多性大鼠(松本氏嗜酸性粒细胞增多症新生大鼠：MES/SDI)。2)所有动物(受试大鼠1500多只)均出现嗜酸性粒细胞增多，并观察到骨髓细胞增殖。3)从抗IL-5的研究结果来看，IL-5在嗜酸性粒细胞增多症的发病机制中起重要作用。4)组织病理学检查发现，骨髓、胃肠道、肠系膜淋巴结和脾的嗜酸性粒细胞增殖和浸润。5)MES大鼠对旋毛虫新生幼虫的感染具有抵抗力。这表明嗜酸性粒细胞在活体内破坏新生幼虫。从这些结果得出结论，MES大鼠可以作为研究HES(人类高嗜酸性粒细胞综合征)的有用的动物模型，因为MES大鼠的高嗜酸性粒细胞增多和许多相关的嗜酸性病变与人类和其他动物的HES的特征相似。

From our research, following results are obtained.1) A quite new strain of spontaneous eosinophilic rat (Matsumoto Eosinophilia shinshu rats: MES/sdi) was produced.2) All animals (more than 1500 rats tested) develop eosinophilia and bone marrow cell proliferation also observed.3) From the results of anti-IL-5 study, it is suggested that IL-5 plays an important roles in pathogenesis of eosinophilia.4) Histopathologically, eosinophilic proliferation and infiltration in the bone marrow, gastrointestinal tract, mesenteric lymph node, and spleen was found.5) MES rats were resistant to infection with T. spiralis newborn larvae. This indicates that eosinophils destroy the newborn larvae in vivo.From these results, it is concluded that MES rats could be a useful animal model for research on HES (Hypereosinophilic syndrome in humans) because the hypereosinophilia, with many associated eosinophilic lesions seen in the MES rats, is comparable to the features of HES in humans and other animals.