Organic synthesis employing liquid/liquid or liquid/solid interface in microchip and development of pile-up-type chemical production system

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The major purpose of this research project is conducting the microchip technology to organic synthesis. In order to realize this concept, following researches were performed.(1)Investigation of the reaction performance of interfacial reaction in microchip(2)Development of novel chemical processes using multiphase flow(3)Realizing mass-producible synthesis using parallel microscale reactions using plural microchipsConcerning (1), diazo-coupling reaction, amidation reaction or alkylation reactions were applied for phasetransfer reactions in microchip, and high performance chemical reactions were successfully performed. Especially, alkylation reaction in microchip showed substrate generality, thus the reaction can be widely applicable for general alkylation reactions. Concerning(2), we developed the segmented flow injection-two phase flow formation system for selective extraction of chemical substances in microchip, the liquid membrane-transport system for molecular transport, and the membrane separation system by preparing chemically-functionalized membrane in microchip, all of which can only realized in microchip. These processes can be applicable for separation of synthesized product in microchip. Concerning (3), 3D-microchannel chip for combinatorial synthesis and mass producible synthesis were developed. These microreactors were applied for amido-compound synthesis, and "massive synthesis" including number of compound and amount of compound was successfully performed using these chips.In conclusion, initial purpose of this research project was totally achieved by the fundamental investigations listed above. We expect these microreactors to be a versatile tool of future organic synthesis.