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Organic synthesis employing liquid/liquid or liquid/solid interface in microchip and development of pile-up-type chemical production system

利用微芯片中液/液或液/固界面的有机合成及堆积型化学生产系统的开发

基本信息

批准号：
13555212
负责人：
HISAMOTO Hideaki
金额：
$ 8.51万
依托单位：
Himeji Institute of Technology (2003)The University of Tokyo (2001-2002)
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

The major purpose of this research project is conducting the microchip technology to organic synthesis. In order to realize this concept, following researches were performed.(1)Investigation of the reaction performance of interfacial reaction in microchip(2)Development of novel chemical processes using multiphase flow(3)Realizing mass-producible synthesis using parallel microscale reactions using plural microchipsConcerning (1), diazo-coupling reaction, amidation reaction or alkylation reactions were applied for phasetransfer reactions in microchip, and high performance chemical reactions were successfully performed. Especially, alkylation reaction in microchip showed substrate generality, thus the reaction can be widely applicable for general alkylation reactions. Concerning(2), we developed the segmented flow injection-two phase flow formation system for selective extraction of chemical substances in microchip, the liquid membrane-transport system for molecular transport, and the membrane separation system by preparing chemically-functionalized membrane in microchip, all of which can only realized in microchip. These processes can be applicable for separation of synthesized product in microchip. Concerning (3), 3D-microchannel chip for combinatorial synthesis and mass producible synthesis were developed. These microreactors were applied for amido-compound synthesis, and "massive synthesis" including number of compound and amount of compound was successfully performed using these chips.In conclusion, initial purpose of this research project was totally achieved by the fundamental investigations listed above. We expect these microreactors to be a versatile tool of future organic synthesis.

本研究计画之主要目的为将微芯片技术应用于有机合成。为了实现这一概念，进行了以下研究。（1）微芯片中界面反应的反应性能研究（2）利用多相流的新型化学过程开发（3）利用多个微芯片的并行微尺度反应实现可批量生产的合成关于（1），重氮偶联反应、酰胺化反应或烷基化反应被应用于微芯片中的相转移反应，并且成功地进行了高性能化学反应。特别是在微芯片上的烷基化反应显示出底物的普遍性，因此该反应可以广泛应用于一般的烷基化反应。关于（2），我们开发了在微芯片中用于选择性萃取化学物质的分段流动注射-两相流形成系统，用于分子传输的液体膜传输系统，以及通过在微芯片中制备化学功能化膜的膜分离系统，所有这些都只能在微芯片中实现。这些方法可应用于微芯片中合成产物的分离。针对（3），开发了用于组合合成和可批量生产合成的三维微通道芯片。将该微反应器应用于酰胺类化合物的合成，并成功实现了化合物数量和化合物量的“批量合成”。我们期望这些微反应器成为未来有机合成的通用工具。