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Development of New Guideline for the Theatment of Bone Cancer Pain.

制定骨癌疼痛治疗新指南。

基本信息

批准号：
13557129
负责人：
YAMAMOTO Tatsuo
金额：
$ 8.77万
依托单位：
Chiba University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-13557129/
关键词：
Bone metastasis Cancer pain COX-1 COX-2 COX-3 NSAIDs opioids WHOの癌性疼痛治療指針癌性疹痛インドメタシン celecoxib SC560 indomethacin NSAID formalin test

项目摘要

Non-steroidal anti-inflammatory drugs (NSAIDs) are clinically used for the treatment of bone cancer pain but the mechanisms NSAIDs use to produce an analgesic effect in patients with bone cancer pain are not fully understood. To explore the mechanisms NSAIDs use to produce an analgesic effect on bone cancer pain, the authors examined the effects of oral administration of a COX-1 selective inhibitor (SC560), a COX-2 selective inhibitor (celecoxib) and a non-selective 4 COX inhibitor (indomethacin) in a mouse bone cancer pain model and compared these effects to the effect of orally administered morphine. Recently, the third COX, COX-3, has been reported. Acetaminophen has been reported to be a selective COX-3 inhibitor. We also examined the effect of acetaminophen on bone cancer pain. Acetaminophen and indomethacin, but not of SC560 and celecoxib, produced an analgesic effect on bone cancer pain. Co-administration of sub-analgesic doses of morphine with acetaminophen enhanced an analgesic effect of acetaminophen. Our data suggested that the oral administration of acetaminophen, but not a COX-1 selective inhibitor and a COX-2 selective inhibitor, produces an analgesic effect on bone cancer pain. The co-administration of acetaminophen with an opioid provides a beneficial effect in the treatment of bone cancer pain.

非甾体抗炎药（NSAIDs）在临床上用于骨癌疼痛的治疗，但NSAIDs在骨癌疼痛患者中产生镇痛作用的机制尚不完全清楚。为了探索非甾体抗炎药对骨癌疼痛产生镇痛作用的机制，作者在小鼠骨癌疼痛模型中检测了口服COX-1选择性抑制剂（SC560）、COX-2选择性抑制剂（塞来昔布）和非选择性4 - COX抑制剂（吲哚美辛）的效果，并将这些效果与口服吗啡的效果进行了比较。最近，第三种COX COX-3被报道。据报道，对乙酰氨基酚是一种选择性COX-3抑制剂。我们还研究了对乙酰氨基酚对骨癌疼痛的影响。对乙酰氨基酚和吲哚美辛对骨癌疼痛有镇痛作用，而SC560和塞来昔布对骨癌疼痛没有镇痛作用。亚镇痛剂量的吗啡与对乙酰氨基酚共同给药可增强对乙酰氨基酚的镇痛作用。我们的数据表明，口服对乙酰氨基酚，而不是COX-1选择性抑制剂和COX-2选择性抑制剂，对骨癌疼痛产生镇痛作用。对乙酰氨基酚与阿片类药物联合使用对骨癌疼痛的治疗有良好的效果。