Development of new central neuropathic pain model

新中枢神经病理性疼痛模型的开发

• 批准号: 23659747
• 负责人: YAMAMOTO Tatsuo
• 金额: $ 2.33万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659747/
• 关键词: 疼痛管理学; 神経障害性疼痛; 神経障害性疼痛モデル; 中枢神経; 視床; 視床痛

Neuropathic pain is defined as pain arising as a direct consequence of a lesion or diseaseaffecting the somatosensory system. There are two types of neuropathic pain, such asperipheral neuropathic pain and central neuropathic pain. Neuropathic pain is known tobe refractory to drug therapy . Especially , central neuropathic pain is an intractable pain. We have no clinically relevant animal central neuropathic pain model and this is why newefficacious therapy was not developed. In this project, I intended to develop new centralneuropathic pain model. I injected blood to various brain regions, such as thalamus. Unfortunately , I could not find any sings of central pain which mimic clinical centralneuropathic pain

神经性疼痛的定义是作为影响躯体感觉系统的病变或疾病的直接后果而产生的疼痛。神经病理性疼痛有两种类型，即周围神经病理性疼痛和中枢性神经病理性疼痛。众所周知，神经病理性疼痛对药物治疗是无效的。尤其是中枢神经病理性疼痛是一种顽固性疼痛。我们没有临床上相关的动物中枢神经病理性疼痛模型，这就是为什么没有开发新的治疗方法。在这个项目中，我打算开发新的中枢神经病理性疼痛模型。我给不同的大脑区域注射了血液，比如丘脑。不幸的是，我找不到任何类似临床中枢性神经病理性疼痛的中枢性疼痛症状。

项目成果

Impaired cognition preceding cardiac surgery is related to cerebral ischemic lesions

心脏手术前的认知受损与脑缺血性病变有关

• 发表时间: 2011
• 期刊: Journal of Anesthesia
• 影响因子: 2.8
• 作者: K. Maekawa;T. Gotō;T. Baba;A. Yoshitake;K. Katahira;Tatsuo Yamamoto
• 通讯作者: Tatsuo Yamamoto

PAG and RVM administration ofN-Acetyl-aspartyl- glutamate (NAAG)peptidase inhibitors is analgesic ininflammatory pain via mGluR3activation and inhibition ofglutamate release

PAG 和 RVM 施用 N-乙酰基-天冬氨酰-谷氨酸 (NAAG) 肽酶抑制剂可通过 mGluR3 激活和谷氨酸释放抑制来镇痛炎性疼痛

• 发表时间: 2011
• 作者: Yamada T;Yamamoto T;Zuo D;Neale JH
• 通讯作者: Neale JH

N-acetyl-aspartylglutamate (NAAG) peptidase inhibitoris analgesic in rat formalin test viamGluR3 activation

N-乙酰-天冬氨酰谷氨酸 (NAAG) 肽酶抑制剂通过 mGluR3 激活在大鼠福尔马林试验中镇痛

• 发表时间: 2012
• 作者: Yamada T;Shinozaki T;Ishimura T,Yamamoto T
• 通讯作者: Ishimura T,Yamamoto T

BiP, an endoplastic reticulumchaperone, modulate the develop- mentof morphine withdrawal syndrome

BiP，一种内质网状伴侣，调节吗啡戒断综合征的发展

• 发表时间: 2011
• 作者: Shinozaki T;Aoe T;Yamamoto T
• 通讯作者: Yamamoto T

Efficacy of morphine, pregabalin, gabapentin and duloxetine on mechanical allodynia is different from that on neuroma pain in the rat neuropathic pain model

吗啡、普瑞巴林、加巴喷丁和度洛西汀对大鼠神经病理性疼痛模型中机械性异常性疼痛的疗效与对神经瘤疼痛的疗效不同

• 发表时间: 2012
• 期刊: Anesth Analg
• 影响因子: 5.7
• 作者: Miyazaki R;Yamamoto T
• 通讯作者: Yamamoto T