IDENTIFICATION OF GENETIC AND ENVIRONMENTAL FACTORS INVOLVED IN GASTRIC CANCER DEVELOPMENT DUE TO H.PYLORI INFECTION

我们调查了亚洲不同国家幽门螺杆菌感染率与疾病患病率以及胃生理差异的关系。1. 亚洲国家幽门螺杆菌感染率排名如下：中国北部，中国南部，中国中部，韩国，日本，马来西亚，美国。2. 幽门螺杆菌阴性受试者的泌酸能力按性别调整排序如下：美国、马来西亚、中国南部、中国中部，其次是中国北部、韩国、日本。3. 不同国家的胃蛋白酶原I、II、I/II比值及胃泌素水平均无差异。4. 各国GU/DU比值的排名顺序如下：日本，韩国，中国北部，中国中部，马来西亚，中国南部，美国。5. 我们对不同国家的胃癌患者和对照组按性别和年龄调整后的11个细胞因子基因的207个snp进行了检测，发现IL4和IL10基因多态性在日本和韩国与胃癌的发展有很强的相关性，而在其他国家没有发现这种趋势。另一方面，虽然我们检查了50个IL-1β基因的snp，但在任何被测试的国家，它们都没有与胃癌的发展有任何关联。6. 在吸烟、饮酒、盐摄入、热量摄入和香料摄入中，吸烟倾向于与癌症发展有关。此外，盐的摄入不仅与胃癌的发展密切相关，还与胃溃疡的发展密切相关。

We investigated relationship between prevalence of H.pylori infection and disease prevalence as well as difference in gastric physiology among various Asian countries. 1. Rank order of prevalence of H.pylori infection in Asian countries is as follows; northern China, southern China, middle part of China, Korea, Japan, Malaysia, USA. 2. Rank order of capacity of acid secretion of H.pylori negative subjects by adjusting sex and gender is as follows; USA, Malaysisa, souterhn China, middle part of China followed by northern China, Korea, Japan equally. 3. However, none of pepsinogen I, II and I/II ratio, or gastrin level was different among different countries. 4. Rank order of GU/DU ratio in different countries is as follows; Japan, Korea, northern China, middle part of China, Malaysia, southern China, USA. 5. We examined 207 SNPs of 11 cytokine genes in both gastric cancer patients and control subjects adjusted by sex and age in different countries, and found strong association of IL4 and IL10 gene polymorphisms with gastric cancer development in Japan and Korea, but no such tendency was found in other countries. On the other hand, although we checked 50 SNPs of IL-1β gene, none of them had any association with the development of gastric cancer in any country tested. 6. Among smoking, drinking, salt intake, calory intake and intake of spices, smoking tended to have an association with cancer development. Moreover, salt intake had a strong association with the development of not only gastric cancer but,also gastric ulcer.