IDENTIFICATION OF GENETIC AND ENVIRONMENTAL FACTORS INVOLVED IN GASTRIC CANCER DEVELOPMENT DUE TO H.PYLORI INFECTION

我们调查了幽门螺杆菌感染率与疾病患病率之间的关系以及亚洲各国胃生理学的差异。1.亚洲国家幽门螺杆菌感染的患病率排序如下：中国北方、南方、中部、韩国、日本、马来西亚、美国。2.幽门螺杆菌阴性受试者的胃酸分泌能力按性别和性别调整后排序为：美国、马来西亚、中国南部、中国中部、中国北方、韩国、日本。3.而胃蛋白酶原I、II和I/II比值及胃泌素水平在不同国家间无差异。4.各国GU/DU比值的高低顺序为：日本、韩国、中国北方、中国中部、马来西亚、中国南方、美国。5.我们在不同国家的胃癌患者和对照组中检测了11个细胞因子基因的207个SNP，并根据性别和年龄进行了调整，发现IL 4和IL 10基因多态性与日本和韩国的胃癌发生密切相关，但在其他国家没有发现这种趋势。另一方面，虽然我们检查了IL-1β基因的50个SNP，但在任何测试的国家中，它们都与胃癌的发生无关。6.在吸烟、饮酒、盐摄入、卡路里摄入和香料摄入中，吸烟倾向于与癌症发生相关。此外，盐的摄入量不仅与胃癌的发生有很强的关联，而且与胃溃疡的发生也有很强的关联。

We investigated relationship between prevalence of H.pylori infection and disease prevalence as well as difference in gastric physiology among various Asian countries. 1. Rank order of prevalence of H.pylori infection in Asian countries is as follows; northern China, southern China, middle part of China, Korea, Japan, Malaysia, USA. 2. Rank order of capacity of acid secretion of H.pylori negative subjects by adjusting sex and gender is as follows; USA, Malaysisa, souterhn China, middle part of China followed by northern China, Korea, Japan equally. 3. However, none of pepsinogen I, II and I/II ratio, or gastrin level was different among different countries. 4. Rank order of GU/DU ratio in different countries is as follows; Japan, Korea, northern China, middle part of China, Malaysia, southern China, USA. 5. We examined 207 SNPs of 11 cytokine genes in both gastric cancer patients and control subjects adjusted by sex and age in different countries, and found strong association of IL4 and IL10 gene polymorphisms with gastric cancer development in Japan and Korea, but no such tendency was found in other countries. On the other hand, although we checked 50 SNPs of IL-1β gene, none of them had any association with the development of gastric cancer in any country tested. 6. Among smoking, drinking, salt intake, calory intake and intake of spices, smoking tended to have an association with cancer development. Moreover, salt intake had a strong association with the development of not only gastric cancer but,also gastric ulcer.