IDENTIFICATION OF GENETIC AND ENVIRONMENTAL FACTORS INVOLVED IN GASTRIC CANCER DEVELOPMENT DUE TO H.PYLORI INFECTION

幽门螺杆菌感染导致胃癌发生的遗传和环境因素的鉴定

• 批准号: 14406021
• 负责人: CHIBA Tsutomu
• 金额: $ 8.13万
• 依托单位: KYOTO UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14406021/
• 关键词: H.PYLORI; GASTRIC CANCER; GASTRIN; ACID SECRETION; PEPSINOGEN; ATROPHIC GASTRITIS; 食塩; 喫煙; H.pylori; 胃潰瘍; 十二指腸潰瘍; 人種; 遺伝子多型; 食塩摂取; ペプシノーゲム

We investigated relationship between prevalence of H.pylori infection and disease prevalence as well as difference in gastric physiology among various Asian countries. 1. Rank order of prevalence of H.pylori infection in Asian countries is as follows; northern China, southern China, middle part of China, Korea, Japan, Malaysia, USA. 2. Rank order of capacity of acid secretion of H.pylori negative subjects by adjusting sex and gender is as follows; USA, Malaysisa, souterhn China, middle part of China followed by northern China, Korea, Japan equally. 3. However, none of pepsinogen I, II and I/II ratio, or gastrin level was different among different countries. 4. Rank order of GU/DU ratio in different countries is as follows; Japan, Korea, northern China, middle part of China, Malaysia, southern China, USA. 5. We examined 207 SNPs of 11 cytokine genes in both gastric cancer patients and control subjects adjusted by sex and age in different countries, and found strong association of IL4 and IL10 gene polymorphisms with gastric cancer development in Japan and Korea, but no such tendency was found in other countries. On the other hand, although we checked 50 SNPs of IL-1β gene, none of them had any association with the development of gastric cancer in any country tested. 6. Among smoking, drinking, salt intake, calory intake and intake of spices, smoking tended to have an association with cancer development. Moreover, salt intake had a strong association with the development of not only gastric cancer but,also gastric ulcer.

我们调查了亚洲各国幽门螺杆菌感染患病率与疾病患病率之间的关系以及胃生理学的差异。 1. 亚洲各国H.pylori感染流行情况排名如下；华北、华南、华中、韩国、日本、马来西亚、美国。 2、H.pylori阴性受试者的泌酸能力按性别和性别调整排序如下；美国、马来西亚、中国南部、中部其次是中国北部、韩国、日本。 3. 然而，胃蛋白酶原I、II和I/II比值或胃泌素水平在不同国家之间没有差异。 4. 各国GU/DU比例排名顺序如下；日本、韩国、华北、华中、马来西亚、华南、美国。 5.我们检查了不同国家胃癌患者和对照受试者中11个细胞因子基因的207个SNP，并按性别和年龄调整后，发现IL4和IL10基因多态性与日本和韩国胃癌的发生有很强的相关性，但在其他国家没有发现这种趋势。另一方面，尽管我们检查了IL-1β基因的50个SNP，但在任何受测国家中，它们都与胃癌的发展没有任何关联。 6. 在吸烟、饮酒、盐摄入量、卡路里摄入量和香料摄入量中，吸烟往往与癌症的发生有关。此外，盐的摄入量不仅与胃癌的发生密切相关，还与胃溃疡的发生密切相关。

项目成果

Fukui T, Chiba T, et al.: "Immuno-genetic analysis of gastric MALT lymphoma-like lesions induced by Helicobacter pylori infection in neonatally thymectomized mice."Lab Invest. (in press). (2004)

Fukui T、Chiba T 等人：“新生胸腺切除小鼠中幽门螺杆菌感染诱导的胃 MALT 淋巴瘤样病变的免疫遗传学分析。”Lab Invest。

Itoh T, Yoshida M, Chiba T, Kita T, Wakatsuki Y: "A coordinated cytotoxic effect of IFN-γ and cross-reactive antibodies in the pathogenesis of Helicobacter pylori gastritis."Helicobacter. 8. 268-278 (2003)

Itoh T、Yoshida M、Chiba T、Kita T、Wakatsuki Y：“幽门螺杆菌胃炎发病机制中 IFN-γ 和交叉反应抗体的协调细胞毒性作用。”Helicobacter。

Hosotani A, Kawanami C, Watanabe T, Okazaki K, Chiba T: "A role of Helicobacter pylori infection in the development of duodenal ulcer after adult living-related liver transplantation."Transplantation. 76. 702-704 (2003)

Hosotani A、Kawanami C、Watanabe T、Okazaki K、Chiba T：“幽门螺杆菌感染在成人活体相关肝移植后十二指肠溃疡发展中的作用。”移植。

Watanabe N, Chiba T, et al.: "Regression of fundic gland polyps following acquisition of helicobacter pylori"Gut. 51. 742-745 (2002)

Watanabe N、Chiba T 等人：“获得幽门螺杆菌后胃底腺息肉的消退”Gut。

Watanabe N, Chiba T, et al.: "Spontaneous regression of Epstein-Barr virus-associated T-cell lymphoma of the stomach."Gastrointest Endosc. 57. 414-417 (2003)

Watanabe N、Chiba T 等人：“Epstein-Barr 病毒相关胃 T 细胞淋巴瘤的自发消退。”Gastrointest Endosc。