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Brain-Inspired Memory Model

脑启发记忆模型

基本信息

批准号：
14580425
负责人：
HAYASHI Hatsuo
金额：
$ 1.98万
依托单位：
Kyushu Institute of Technology
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2002
资助国家：
日本
起止时间：
2002 至 2004
项目状态：
已结题

项目摘要

We obtained following results using a hippocampal network model based on the physiological knowledge.1.Stochastic resonance took place in the present hippocampal model. The membrane potential fluctuations in CA1 pyramidal cells caused by complex spatiotemporal activity of the CA3 network works as a subthreshold noise, and a periodic perforant path signal to the CA1 network may be regarded as a subthreshold signal.2.Memory patterns stored as spatial patterns of augmented Shaffer collateral synapses were recalled as activity patterns of the CA 1 network taking advantage of the stochastic resonance.3.LTP was induced in Schaffer collateral synapses by the chaotic response of the CA3 network to a periodic stimulation; the CA3 network caused a delta rhythm spontaneously and Schaffer collateral synapses were modified depending on the Ca^<2+> concentration inside the CA1 pyramidal cells.4.Bimodal distribution of recurrent synaptic conductances was achieved in the CA3 network by STDP. The avera … More ge synaptic weight and the frequency of the rhythmic activity were not altered after the convergence of the distribution even if the spatial distribution of synaptic weights was changed by learning, because LTP and LTD were induced simultaneously in recurrent connections.5.When theta burst stimuli were fed into local sites in the CA3 network, radial propagation of neuronal activity was produced from the stimulus sites due to asymmetric augmentation of the recurrent connections. This radial propagation is regarded as a short-term memory because the propagation is repeated for about 30 s after the termination of stimuli ; the radial patterns of synaptic weight are modified with time by the spontaneous activity of the CA3 network through STDP.6.Neurons in the CA1 network learned temporal sequence of signals fed into the hippocampal model using the radial propagation of neuronal activity in the CA3 network when Schaffer collateral synapses were subject to a STDP rule, besides recurrent synapses in the CA3 network. Less

利用基于生理学知识的海马网络模型，我们得到了以下结果：1.在本海马模型中发生了随机共振。由CA 3网络的复杂时空活动引起的CA 1锥体细胞中的膜电位波动作为阈下噪声起作用，2.以增强Shaffer侧支突触的空间模式存储的记忆模式被回忆为CA 1网络的活动模式，利用随机共振的优势。CA 3网络对周期性刺激的混沌反应在Schaffer侧支突触中诱导，CA 3网络自发地引起δ节律，Schaffer侧支突触根据CA 1锥体细胞内的Ca^<2+>浓度而改变。4. STDP在CA 3网络中实现了突触传导的双峰分布。平均值 ...更多信息即使学习改变了突触重量的空间分布，突触重量和节律活动的频率在分布收敛后也没有改变，因为LTP和LTD在递归连接中同时被诱导。5.当θ爆发刺激被馈送到CA 3网络中的局部位点时，神经元活动的径向传播是由刺激部位产生的，这是由于复发性连接的不对称增强。这种径向传播被认为是一种短期记忆，因为在刺激终止后，这种传播会重复大约30 s; CA 3网络通过STDP自发性活动改变了突触权重的径向模式。6. CA 1网络中的神经元利用CA 3网络中神经元活动的径向传播来学习馈入海马模型的信号的时间序列当Schaffer侧支突触受到STDP规则，除了在CA 3网络中的复发性突触。少